C57BL/6NCrl-Parp1em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:15075
International strain nameC57BL/6NCrl-Parp1em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolParp1em1(IMPC)Ccpcz
Gene/Transgene symbolParp1

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • abnormal spleen morphology / IMPC
  • enlarged spleen / IMPC
  • abnormal uterus morphology / IMPC
  • small seminal vesicle / IMPC
  • microphthalmia / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased circulating creatinine level / IMPC
  • increased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • decreased grip strength / IMPC
  • decreased total retina thickness / IMPC
  • decreased NK cell number / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal spleen morphology / IMPC
  • abnormal uterus morphology / IMPC
  • abnormal eye morphology / IMPC
  • increased prepulse inhibition / IMPC
  • small seminal vesicle / IMPC
  • immune system phenotype / IMPC
  • increased circulating creatinine level / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • microphthalmia / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • enlarged spleen / IMPC
  • abnormal retina inner nuclear layer morphology / IMPC
MGI phenotypes (gene matching)
  • decreased cell proliferation / MGI
  • skin hyperplasia / MGI
  • decreased body weight / MGI
  • increased mortality induced by gamma-irradiation / MGI
  • abnormal inflammatory response / MGI
  • decreased inflammatory response / MGI
  • decreased litter size / MGI
  • abnormal macrophage physiology / MGI
  • enhanced wound healing / MGI
  • no phenotypic analysis / MGI
  • abnormal leukocyte migration / MGI
  • decreased neuron apoptosis / MGI
  • abnormal response/metabolism to endogenous compounds / MGI
  • abnormal microglial cell physiology / MGI
  • elevated level of mitotic sister chromatid exchange / MGI
  • increased mortality induced by ionizing radiation / MGI
  • induced chromosome breakage / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • abnormal cell cycle checkpoint function / MGI
  • decreased susceptibility to noise-induced hearing loss / MGI
  • decreased susceptibility to injury / MGI
  • immune system phenotype / MGI
  • increased renal glomerular filtration rate / MGI
  • decreased circulating creatinine level / MGI
  • increased apoptosis / MGI
  • abnormal DNA repair / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • decreased circulating interleukin-1 beta level / MGI
  • decreased susceptibility to endotoxin shock / MGI
  • decreased physiological sensitivity to xenobiotic / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • decreased renal tubule apoptosis / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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