C57BL/6J-Iap5-1solo/H

Status

Available to order

EMMA IDEM:15067
International strain nameC57BL/6J-Iap5-1solo/H
Alternative nameB6J Iap5-1soloAce
Strain typeSpontaneous
Allele/Transgene symbolIap5-1solo,
Gene/Transgene symbolIap5-1

Information from provider

ProviderAnne Ferguson-Smith
Provider affiliationGenetics, University of Cambridge
Genetic informationThis strain carries the solo LTR variant of the genetically induced intracisternal A-particle, located near to coding gene Pgm2 on chromosome 5 (Iap5-1solo). This is the unmethylated variant of this locus (Iap5-1full or B6JIap5-1fullAce is the methylated variant; EMMA strain EM:15019) whose epigenetic state is established during early preimplantation.
Phenotypic informationHomozygous:
Mild metabolic phenotype depending on the methylation at the IAP.

Heterozygous:
Mild metabolic phenotype depending on the methylation at the IAP.
Breeding historyThese are maintained as a homozygous colony.
References
  • A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.;Bertozzi Tessa M, Takahashi Nozomi, Hanin Geula, Kazachenka Anastasiya, Ferguson-Smith Anne C, ;2021;eLife;10;; 33755012
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

  • A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.;Bertozzi Tessa M, Takahashi Nozomi, Hanin Geula, Kazachenka Anastasiya, Ferguson-Smith Anne C, ;2021;eLife;10;; 33755012

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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