C57BL/6J-Iap5-1solo/H
| Status | Available to order |
| EMMA ID | EM:15067 |
| International strain name | C57BL/6J-Iap5-1solo/H |
| Alternative name | B6J Iap5-1soloAce |
| Strain type | Spontaneous |
| Allele/Transgene symbol | Iap5-1solo |
| Gene/Transgene symbol | Iap5-1 |
Information from provider
| Provider | Anne Ferguson-Smith |
| Provider affiliation | Genetics, University of Cambridge |
| Genetic information | This strain carries the solo LTR variant of the genetically induced intracisternal A-particle, located near to coding gene Pgm2 on chromosome 5 (Iap5-1solo). This is the unmethylated variant of this locus (Iap5-1full or B6JIap5-1fullAce is the methylated variant; EMMA strain EM:15019) whose epigenetic state is established during early preimplantation. |
| Phenotypic information | Homozygous:Mild metabolic phenotype depending on the methylation at the IAP.Heterozygous:Mild metabolic phenotype depending on the methylation at the IAP. |
| Breeding history | These are maintained as a homozygous colony. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.;Bertozzi Tessa M, Takahashi Nozomi, Hanin Geula, Kazachenka Anastasiya, Ferguson-Smith Anne C, ;2021;eLife;10;; 33755012