C57BL/6NCrl-Nrp1em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:15049
International strain nameC57BL/6NCrl-Nrp1em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolNrp1em1(IMPC)Ccpcz
Gene/Transgene symbolNrp1

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
  • decreased prepulse inhibition / IMPC
  • abnormal auditory brainstem response / IMPC
MGI phenotypes (gene matching)
  • abnormal vascular development / MGI
  • abnormal pulmonary artery morphology / MGI
  • abnormal corpus callosum morphology / MGI
  • abnormal hippocampus morphology / MGI
  • abnormal facial motor nucleus morphology / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • abnormal cranial nerve morphology / MGI
  • abnormal trigeminal nerve morphology / MGI
  • abnormal facial nerve morphology / MGI
  • abnormal vestibulocochlear nerve morphology / MGI
  • abnormal spinal nerve morphology / MGI
  • decreased body size / MGI
  • disorganized yolk sac vascular plexus / MGI
  • postnatal growth retardation / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal dendritic cell physiology / MGI
  • abnormal T cell physiology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal pharyngeal arch artery morphology / MGI
  • abnormal retinal vasculature morphology / MGI
  • abnormal axon guidance / MGI
  • dilated heart atrium / MGI
  • decreased tumor growth/size / MGI
  • nervous system phenotype / MGI
  • vascular smooth muscle hypoplasia / MGI
  • transposition of great arteries / MGI
  • abnormal coronary artery morphology / MGI
  • right aortic arch / MGI
  • double aortic arch / MGI
  • abnormal dorsal aorta morphology / MGI
  • abnormal brain vasculature morphology / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • decreased angiogenesis / MGI
  • abnormal neuronal migration / MGI
  • abnormal fourth pharyngeal arch artery morphology / MGI
  • abnormal sixth pharyngeal arch artery morphology / MGI
  • abnormal third pharyngeal arch artery morphology / MGI
  • abnormal induced retinal neovascularization / MGI
  • abnormal retinal blood vessel morphology / MGI
  • abnormal retinal blood vessel pattern / MGI
  • abnormal first pharyngeal arch artery morphology / MGI
  • abnormal second pharyngeal arch artery morphology / MGI
  • abnormal aortic arch and aortic arch branch attachment / MGI
  • abnormal coronary vessel morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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