B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H
| Status | Available to order |
| EMMA ID | EM:15026 |
| Citation information | RRID:IMSR_EM:15026 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H |
| Alternative name | C57BL/6J-Tg(Bmx-cre/ERT2)1Rha |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Bmx-cre/ERT2)1Rha |
| Gene/Transgene symbol | Tg(Bmx-cre/ERT2)1Rha |
Information from provider
| Provider | Ralph H Adams |
| Provider affiliation | Max Planck Institute for Molecular Biomedicine |
| Genetic information | An inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter; cre recombination is inducible via administration of tamoxifen. Useful for study of angiogenesis, atherosclerosis and neovascularization. Non-induced Bmx-CreERT2 mice demonstrate no cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+). |
| Phenotypic information | Homozygous:Not knownHeterozygous:Normal appearance |
| Breeding history | Founder lines were backcrossed to C57BL/6 for at least five generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053