B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H

Status	Available to order
EMMA ID	EM:15026
International strain name	B6.Cg-Tg(Bmx-cre/ERT2)1Rha/H
Alternative name	C57BL/6J-Tg(Bmx-cre/ERT2)1Rha
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Bmx-cre/ERT2)1Rha
Gene/Transgene symbol	Tg(Bmx-cre/ERT2)1Rha

Information from provider

Provider	Ralph H Adams
Provider affiliation	Max Planck Institute for Molecular Biomedicine
Genetic information	An inducible cre deleter under the control of the BMX non-receptor tyrosine kinase promoter; cre recombination is inducible via administration of tamoxifen. Useful for study of angiogenesis, atherosclerosis and neovascularization. Non-induced Bmx-CreERT2 mice demonstrate no cre recombinase activity, while tamoxifen-induced Bmx-CreERT2 mice demonstrate high levels of recombinase-mediated gene deletion in endothelial cells (95%+).
Phenotypic information	Homozygous: Not known Heterozygous: Normal appearance
Breeding history	Founder lines were backcrossed to C57BL/6 for at least five generations.
References	Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

Notch controls retinal blood vessel maturation and quiescence.;Ehling Manuel, Adams Susanne, Benedito Rui, Adams Ralf H, ;2013;Development (Cambridge, England);140;3051-61; 23785053

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

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