- hydronephrosis / MGI
- abnormal kidney cortex morphology / MGI
- abnormal kidney blood vessel morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- hyperactivity / MGI
- polydipsia / MGI
- hypotension / MGI
- polyuria / MGI
- abnormal postnatal growth/weight/body size / MGI
- abnormal kidney morphology / MGI
- decreased circulating aldosterone level / MGI
- dilated renal tubules / MGI
- abnormal juxtaglomerular apparatus morphology / MGI
- decreased heart weight / MGI
- increased systemic arterial blood pressure / MGI
- decreased systemic arterial blood pressure / MGI
- decreased urine osmolality / MGI
- renal interstitial fibrosis / MGI
- increased circulating renin level / MGI
- decreased ovulation rate / MGI
- decreased liver weight / MGI
- increased kidney weight / MGI
- decreased renal glomerulus number / MGI
- dilated kidney collecting duct / MGI
- kidney atrophy / MGI
- abnormal blood-brain barrier function / MGI
- abnormal enzyme/coenzyme level / MGI
- abnormal renal glomerulus morphology / MGI
- renal/urinary system phenotype / MGI
- cardiovascular system phenotype / MGI
- reproductive system phenotype / MGI
- vascular smooth muscle hyperplasia / MGI
- abnormal renal/urinary system physiology / MGI
- increased renal plasma flow rate / MGI
- increased circulating creatinine level / MGI
- abnormal renal filtration rate / MGI
- decreased creatinine clearance / MGI
- increased circulating antidiuretic hormone level / MGI
- decreased urine potassium level / MGI
- decreased systemic arterial diastolic blood pressure / MGI
- decreased systemic arterial systolic blood pressure / MGI
- decreased urine sodium level / MGI
- increased circulating angiotensinogen level / MGI
- decreased circulating angiotensinogen level / MGI
- abnormal hippocampus granule cell layer / MGI
- slow postnatal weight gain / MGI
- decreased fat cell size / MGI
- decreased epididymal fat pad weight / MGI
- abnormal blood homeostasis / MGI
- decreased total body fat amount / MGI
- postnatal lethality, incomplete penetrance / MGI
- kidney papillary atrophy / MGI
- abnormal kidney afferent arteriole morphology / MGI
- abnormal kidney cortex artery morphology / MGI
- abnormal kidney interlobular artery morphology / MGI
- abnormal kidney inner medulla morphology / MGI
- renal tubule atrophy / MGI
- expanded mesangial matrix / MGI
- tubulointerstitial nephritis / MGI
- kidney medulla atrophy / MGI
- kidney cortex atrophy / MGI
- increased urine flow rate / MGI
- decreased urine aldosterone level / MGI
- increased urine antidiuretic hormone level / MGI
- kidney papillary hypoplasia / MGI
- increased fluid intake / MGI
C57BL/6NTac-Agtem1(IMPC)H/H
Status | Available to order |
EMMA ID | EM:14999 |
International strain name | C57BL/6NTac-Agtem1(IMPC)H/H |
Alternative name | |
Strain type | Endonuclease-mediated |
Allele/Transgene symbol | Agtem1(IMPC)H |
Gene/Transgene symbol | Agt |
Information from provider
Provider | MRC, Medical Research Council |
Provider affiliation | Mary Lyon Centre at MRC Harwell |
Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Primary hyperoxaluria type 1 / Orphanet_93598
- Renal tubular dysgenesis of genetic origin / Orphanet_97369
MGI phenotypes (gene matching)
Information on how we integrate external resources can be found here
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