C57BL/6NTac-Cd44em1(IMPC)H/H

Status

Available to order

EMMA IDEM:14997
International strain nameC57BL/6NTac-Cd44em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolCd44em1(IMPC)H
Gene/Transgene symbolCd44

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (gene matching)
  • decreased mast cell number / MGI
  • altered response to myocardial infarction / MGI
  • abnormal cell morphology / MGI
  • decreased mast cell histamine storage / MGI
  • abnormal uterus morphology / MGI
  • thin epidermis / MGI
  • abnormal lipid level / MGI
  • abnormal vasculogenesis / MGI
  • abnormal digestive system physiology / MGI
  • impaired wound healing / MGI
  • impaired macrophage phagocytosis / MGI
  • liver inflammation / MGI
  • lung inflammation / MGI
  • abnormal definitive hematopoiesis / MGI
  • no abnormal phenotype detected / MGI
  • abnormal CD4-positive, alpha beta T cell morphology / MGI
  • abnormal neutrophil physiology / MGI
  • short tibia / MGI
  • impaired skin barrier function / MGI
  • delayed wound healing / MGI
  • decreased myocardial infarction size / MGI
  • abnormal leukocyte migration / MGI
  • peritoneal inflammation / MGI
  • decreased susceptibility to induced arthritis / MGI
  • decreased tumor growth/size / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal physiological neovascularization / MGI
  • increased susceptibility to induced arthritis / MGI
  • enhanced coordination / MGI
  • decreased cholesterol level / MGI
  • abnormal vascular endothelial cell physiology / MGI
  • decreased susceptibility to kidney reperfusion injury / MGI
  • abnormal miniature excitatory postsynaptic currents / MGI
  • decreased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • increased mean systemic arterial blood pressure / MGI
  • abnormal CD8-positive, alpha beta T cell morphology / MGI
  • abnormal response to infection / MGI
  • increased susceptibility to parasitic infection / MGI
  • impaired natural killer cell mediated cytotoxicity / MGI
  • decreased acute inflammation / MGI
  • increased acute inflammation / MGI
  • decreased T cell proliferation / MGI
  • digestive/alimentary phenotype / MGI
  • immune system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal CD4-positive, alpha-beta T cell physiology / MGI
  • abnormal T-helper 1 physiology / MGI
  • abnormal T-helper 2 physiology / MGI
  • choroidal neovascularization / MGI
  • decreased circulating creatinine level / MGI
  • decreased blood urea nitrogen level / MGI
  • abnormal vascular smooth muscle physiology / MGI
  • decreased angiogenesis / MGI
  • decreased susceptibility to type IV hypersensitivity reaction / MGI
  • abnormal cell physiology / MGI
  • abnormal vascular endothelial cell morphology / MGI
  • abnormal involution of the mammary gland / MGI
  • increased diameter of tibia / MGI
  • abnormal osteoclast differentiation / MGI
  • increased circulating tumor necrosis factor level / MGI
  • decreased circulating tumor necrosis factor level / MGI
  • increased tumor necrosis factor secretion / MGI
  • abnormal interleukin secretion / MGI
  • increased circulating interferon-gamma level / MGI
  • increased circulating interleukin-2 level / MGI
  • increased interleukin-1 beta secretion / MGI
  • increased interleukin-10 secretion / MGI
  • increased interleukin-6 secretion / MGI
  • impaired neutrophil recruitment / MGI
  • abnormal chemokine secretion / MGI
  • decreased transforming growth factor level / MGI
  • decreased sensitivity to induced cell death / MGI
  • abnormal epidermal lamellar body morphology / MGI
  • increased sensitivity to induced morbidity/mortality / MGI
  • abnormal circulating chemokine level / MGI
  • abnormal circulating cytokine level / MGI
  • decreased activation-induced cell death of T cells / MGI
  • increased mitochondria size / MGI
  • abnormal mitochondrial crista morphology / MGI
  • decreased fibroblast proliferation / MGI
  • impaired leukocyte tethering or rolling / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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