C57BL/6N-Tg(Sox2-cre/ERT2)194.34Ics/Ics
| Status | Available to order |
| EMMA ID | EM:14970 |
| International strain name | C57BL/6N-Tg(Sox2-cre/ERT2)194.34Ics/Ics |
| Alternative name | Tg(Sox2-CreERT2)194.34.Ics |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Sox2-cre/ERT2)194.34Ics |
| Gene/Transgene symbol | Tg(Sox2-cre/ERT2)194.34Ics |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | The line was obtained by microinjection of a circular murine BAC transgene (RP23-423J10), previously modified by recombineering at the ATG of the Sox2 gene of a rabbit-b-globin intron-CreERT2 cassette followed by a flipped PGK-Tn5-Kana/NeoR cassette. The genetic background of the fertilized oocytes was C57BL/6N. The founder was then maintained in a C57BL/6N genetic background. The subline 194.34 was analyzed and cryopreserved. The information available on the characterization of the line, e.g. expression analysis, histology, paper reference, is available on the web page linked here. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Backcrossed to C57BL/6N for 13 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Skin progenitor cells contribute to bleomycin-induced skin fibrosis.;Liu Shangxi, Herault Yann, Pavlovic Guillaume, Leask Andrew, ;2014;Arthritis & rheumatology (Hoboken, N.J.);66;707-13; 24574231