C57BL/6N-Tg(Sox2-cre/ERT2)194.34Ics/Ics

Status	Available to order
EMMA ID	EM:14970
Citation information	RRID:IMSR_EM:14970 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-Tg(Sox2-cre/ERT2)194.34Ics/Ics
Alternative name	Tg(Sox2-CreERT2)194.34.Ics
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Sox2-cre/ERT2)194.34Ics
Gene/Transgene symbol	Tg(Sox2-cre/ERT2)194.34Ics

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	The line was obtained by microinjection of a circular murine BAC transgene (RP23-423J10), previously modified by recombineering at the ATG of the Sox2 gene of a rabbit-b-globin intron-CreERT2 cassette followed by a flipped PGK-Tn5-Kana/NeoR cassette. The genetic background of the fertilized oocytes was C57BL/6N. The founder was then maintained in a C57BL/6N genetic background. The subline 194.34 was analyzed and cryopreserved. The information available on the characterization of the line, e.g. expression analysis, histology, paper reference, is available on the web page linked here.
Phenotypic information	Homozygous: NA Heterozygous: NA
Breeding history	Backcrossed to C57BL/6N for 13 generations.
References	Skin progenitor cells contribute to bleomycin-induced skin fibrosis.;Liu Shangxi, Herault Yann, Pavlovic Guillaume, Leask Andrew, ;2014;Arthritis & rheumatology (Hoboken, N.J.);66;707-13; 24574231
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

Skin progenitor cells contribute to bleomycin-induced skin fibrosis.;Liu Shangxi, Herault Yann, Pavlovic Guillaume, Leask Andrew, ;2014;Arthritis & rheumatology (Hoboken, N.J.);66;707-13; 24574231

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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