B6N.Cg-Tg(Ins1-cre/ERT2)16.7Ics/Ics
| Status | Available to order |
| EMMA ID | EM:14954 |
| International strain name | B6N.Cg-Tg(Ins1-cre/ERT2)16.7Ics/Ics |
| Alternative name | Tg(Ins1-CreERT2)16.7.Ics |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Ins1-cre/ERT2)16.7Ics |
| Gene/Transgene symbol | Tg(Ins1-cre/ERT2)16.7Ics |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | The line was obtained by microinjection of a plasmid transgene containing 8.1 kb of the mouse Ins1 promoter region followed by a rabbit-b-globin intron-CreERT2 cassette and a SV40 polyA sequence. The genetic background of the fertilized oocytes was C57BL/6J x SJL/J. The founder was then maintained in a C57BL/6J genetic background. The subline 16.7 was analyzed and cryopreserved. Four copies of transgene are inserted on mouse Chr12. The information available on the characterization of the line, e.g. expression analysis, histology, paper reference, is available on the web page linked here. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Backcrossed to C57BL/6N for 9 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Rfx6 maintains the functional identity of adult pancreatic β cells.;Piccand Julie, Strasser Perrine, Hodson David J, Meunier Aline, Ye Tao, Keime Céline, Birling Marie-Christine, Rutter Guy A, Gradwohl Gérard, ;2014;Cell reports;9;2219-32; 25497096