B6N.Cg-Tg(Col1a1-cre/ERT2)6.1Ics/Ics
| Status | Available to order |
| EMMA ID | EM:14947 |
| International strain name | B6N.Cg-Tg(Col1a1-cre/ERT2)6.1Ics/Ics |
| Alternative name | Tg(Col1a1-creERT2)6.1.Ics |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Col1a1-cre/ERT2)6.1Ics |
| Gene/Transgene symbol | Tg(Col1a1-cre/ERT2)6.1Ics |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | The line was obtained by microinjection of a circular murine BAC transgene (RP23-53E2), previously modified by recombineering at the ATG of the Col1a1 gene of a rabbit-b-globin intron-CreERT2 cassette followed by a flipped PGK-Tn5-Kana/NeoR cassette. The genetic background of the fertilized oocytes was C57BL/6J x SJL/J. The founder was then backcrossed to a C57BL/6J genetic background. The subline 6.1 was analyzed and cryopreserved. The information available on the characterization of the line, e.g. expression analysis, histology, paper reference, is available on the web page linked here. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Backcrossed to C57BL/6N for 11 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Literature references
- Distinct origin and region-dependent contribution of stromal fibroblasts to fibrosis following traumatic injury in mice.;Holl Daniel, Hau Wing Fung, Julien Anais, Banitalebi Shervin, Kalkitsas Jannis, Savant Soniya, Llorens-Bobadilla Enric, Herault Yann, Pavlovic Guillaume, Amiry-Moghaddam Mahmood, Dias David Oliveira, Göritz Christian, ;2024;Nature neuroscience;27;1285-1298; 38849523