B6N.Cg-Tg(CamkIIa-cre/ERT2)127.29Ics/Ics

Status	Available to order
EMMA ID	EM:14941
International strain name	B6N.Cg-Tg(CamkIIa-cre/ERT2)127.29Ics/Ics
Alternative name	Tg(CamkIIa-creERT2)127.29.Ics
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Camk2a-cre/ERT2)127.29Ics
Gene/Transgene symbol	Tg(Camk2a-cre/ERT2)127.29Ics

Information from provider

Provider	ICS, Institut Clinique de la Souris
Provider affiliation	ICS, Institut Clinique de la Souris
Genetic information	The line was obtained by microinjection of a transgene composed of cassette containing the mouse 8.5 kb CamkIIa promoter region, a rabbit-b-globin intron, the CreERT2 cDNA and a SV40 pA cassette. The genetic background of the fertilized oocytes was C57BL/6J x SJL/J. The founder was then backcrossed to a C57BL/6J genetic background. The subline 127.29 was analyzed and cryopreserved. Twelve copies of transgene are inserted on mouse Chr5. The creERT2 expression has been show to be specific. The information available on the characterization of the line, e.g. expression analysis, histology, paper reference, is available on the web page linked here.
Phenotypic information	Homozygous: NA Heterozygous: NA
Breeding history	Backcrossed to C57BL/6N for 8 generations.
References	Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.;Dubos Aline, Castells-Nobau Anna, Meziane Hamid, Oortveld Merel A W, Houbaert Xander, Iacono Giovanni, Martin Christelle, Mittelhaeuser Christophe, Lalanne Valérie, Kramer Jamie M, Bhukel Anuradha, Quentin Christine, Slabbert Jan, Verstreken Patrik, Sigrist Stefan J, Messaddeq Nadia, Birling Marie-Christine, Selloum Mohammed, Stunnenberg Henk G, Humeau Yann, Schenck Annette, Herault Yann, ;2015;Human molecular genetics;24;6736-55; 26376863
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France

Literature references

Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration.;Dubos Aline, Castells-Nobau Anna, Meziane Hamid, Oortveld Merel A W, Houbaert Xander, Iacono Giovanni, Martin Christelle, Mittelhaeuser Christophe, Lalanne Valérie, Kramer Jamie M, Bhukel Anuradha, Quentin Christine, Slabbert Jan, Verstreken Patrik, Sigrist Stefan J, Messaddeq Nadia, Birling Marie-Christine, Selloum Mohammed, Stunnenberg Henk G, Humeau Yann, Schenck Annette, Herault Yann, ;2015;Human molecular genetics;24;6736-55; 26376863

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.