C57BL/6-Sparctm1c(EUCOMM)Wtsi/Orl

Status

Available to order

EMMA IDEM:14932
Citation informationRRID:IMSR_EM:14932 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6-Sparctm1c(EUCOMM)Wtsi/Orl
Alternative nameSparc-tm1c
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolSparctm1c(EUCOMM)Wtsi
Gene/Transgene symbolSparc

Information from provider

ProviderCécile FREMOND
Provider affiliationCNRS-TAAM-CDTA-UAR44
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0060_1_A07. For further details on the construction of this clone see the relevant page at the IMPC portal (https://www.mousephenotype.org/data/alleles/MGI:98373/tm1a(EUCOMM)Wtsi). Rederived tm1a mice (EMMA strain EM:05296) have been crossed with flp recombinase-deleter mice (EMMA strain EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele.
Phenotypic informationHomozygous:
Homozygous mice have not been generated.

Heterozygous:
Nothing
Breeding historyRederived tm1a mice (EMMA strain EM:05296) have been crossed with flp-deleter mice EMMA strain EM:05490) to obtain the tm1c allele.
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous B6Brd;B6N-Tyrc-Brd males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • abnormal coat/hair pigmentation / IMPC
  • increased lactate dehydrogenase level / IMPC
  • abnormal incisor color / IMPC
  • abnormal humerus morphology / IMPC
  • decreased body weight / IMPC
  • increased circulating creatine kinase level / IMPC
  • abnormal lens morphology / IMPC
  • decreased bone mineral density / IMPC
  • decreased body length / IMPC
  • cataract / IMPC
  • abnormal tibia morphology / IMPC
  • abnormal eye morphology / IMPC
  • abnormal tooth morphology / IMPC
  • decreased bone mineral content / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased circulating calcium level / IMPC
  • abnormal coat/ hair morphology / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • abnormal trabecular bone morphology / MGI
  • abnormal tibia morphology / MGI
  • decreased body weight / MGI
  • abnormal lens morphology / MGI
  • cataract / MGI
  • retinal degeneration / MGI
  • hypoactivity / MGI
  • abnormal skeleton physiology / MGI
  • abnormal bone strength / MGI
  • eye inflammation / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal eye morphology / MGI
  • abnormal tooth morphology / MGI
  • enhanced wound healing / MGI
  • abnormal lens fiber morphology / MGI
  • delayed wound healing / MGI
  • abnormal bone remodeling / MGI
  • retinal detachment / MGI
  • abnormal lens capsule morphology / MGI
  • abnormal lens epithelium morphology / MGI
  • increased tumor growth/size / MGI
  • abnormal retinal layer morphology / MGI
  • abnormal osteoclast morphology / MGI
  • decreased osteoclast cell number / MGI
  • abnormal osteoblast morphology / MGI
  • decreased osteoblast cell number / MGI
  • abnormal humerus morphology / MGI
  • hematopoietic system phenotype / MGI
  • abnormal skeleton morphology / MGI
  • decreased mean corpuscular hemoglobin concentration / MGI
  • vitreous body inflammation / MGI
  • ruptured lens capsule / MGI
  • abnormal incisor color / MGI
  • subcapsular cataracts / MGI
  • posterior subcapsular cataracts / MGI
  • cortical cataracts / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).