IMPC phenotypes (gene matching)
B6N(Cg)-Palmdtm1.1Kili/Ieg
| Status | Available to order |
| EMMA ID | EM:14922 |
| International strain name | B6N(Cg)-Palmdtm1.1Kili/Ieg |
| Alternative name | Palmd-tm1.1Kili (official allele design., MGI:6477925) lab. design.: Palmdc (conditional Palmd-KO) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Palmdtm1.1Kili |
| Gene/Transgene symbol | Palmd |
Information from provider
| Provider | Manfred Kilimann |
| Provider affiliation | Molecular Neurobiology, MPI for Multidisciplinarc Sciences |
| Genetic information | Exons 4-6 of the mouse Palmd gene are flanked en-bloc by loxP sites in introns 3 and 6, generated by homologous recombination. This provides the option for deleting this DNA interval by cre recombinase, resulting in a frame-shift. Germ-line cre deletion of this allele has been carried out, generating the constitutive Palmdtm1.2Kili knock-out line (EMMA strain EM:14923), which is a proven null mutant with undetectable Palmd protein expression (detection limit of Western blot analysis: |
| Phenotypic information | Homozygous:No phenotype.Heterozygous:No phenotype. |
| Breeding history | Mice were generated in a C57BL/6N ES cell line and subsequently backcrossed to C57BL/6N mice for more than 5 generations. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Literature references
- Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.;Sáinz-Jaspeado Miguel, Smith Ross O, Plunde Oscar, Pawelzik Sven-Christian, Jin Yi, Nordling Sofia, Ding Yindi, Aspenström Pontus, Hedlund Marie, Bastianello Giulia, Ascione Flora, Li Qingsen, Demir Cansaran Saygili, Fernando Dinesh, Daniel Geoffrey, Franco-Cereceda Anders, Kroon Jeffrey, Foiani Marco, Petrova Tatiana V, Kilimann Manfred W, Bäck Magnus, Claesson-Welsh Lena, ;2021;Circulation;144;1629-1645; 34636652