B6;CBA-Tg(Cyp1a1-cre)1Dwi/H
| Status | Available to order |
| EMMA ID | EM:14903 |
| Citation information | RRID:IMSR_EM:14903 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Tg(Cyp1a1-cre)1Dwi/H |
| Alternative name | Tg(Cyp1a1-cre)1Dwi -Published as (AhCre) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cyp1a1-cre)1Dwi |
| Gene/Transgene symbol | Tg(Cyp1a1-cre)1Dwi |
Information from provider
| Provider | Douglas Winton |
| Provider affiliation | Cancer Research UK Cambridge Institute, University of Cambridge |
| Genetic information | An AhCre transgene vector, containing the cre recombinase coding sequence under the rat CYP1A1 promoter, was injected into fertilized C57BL/6 x CBA oocytes. Founder mice were backcrossed onto C57BL/6 mice to establish transgenic lines. Heterozygous transgenic lines were interbred to establish homozygous AhCre mice. |
| Phenotypic information | Homozygous:None breeds to homozygosityHeterozygous:No phenotype |
| Breeding history | The line was cryopreserved many years ago. It was created around 2002/3 by pronuclear injection of B6 x CBA embryos and maintained as pairs of trios mainly comprised of transgenic males crossed to wild-type females. Initial wild-type breeders were B6. But the line is not congenic to B6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783
- Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325