B6;CBA-Tg(Cyp1a1-cre)1Dwi/H

Status	Available to order
EMMA ID	EM:14903
International strain name	B6;CBA-Tg(Cyp1a1-cre)1Dwi/H
Alternative name	Tg(Cyp1a1-cre)1Dwi -Published as (AhCre)
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Cyp1a1-cre)1Dwi
Gene/Transgene symbol	Tg(Cyp1a1-cre)1Dwi

Information from provider

Provider	Douglas Winton
Provider affiliation	Cancer Research UK Cambridge Institute, University of Cambridge
Genetic information	An AhCre transgene vector, containing the cre recombinase coding sequence under the rat CYP1A1 promoter, was injected into fertilized C57BL/6 x CBA oocytes. Founder mice were backcrossed onto C57BL/6 mice to establish transgenic lines. Heterozygous transgenic lines were interbred to establish homozygous AhCre mice.
Phenotypic information	Homozygous: None breeds to homozygosity Heterozygous: No phenotype
Breeding history	The line was cryopreserved many years ago. It was created around 2002/3 by pronuclear injection of B6 x CBA embryos and maintained as pairs of trios mainly comprised of transgenic males crossed to wild-type females. Initial wild-type breeders were B6. But the line is not congenic to B6.
References	Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783 Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin.;Ireland Heather, Kemp Richard, Houghton Carol, Howard Louise, Clarke Alan R, Sansom Owen J, Winton Douglas J, ;2004;Gastroenterology;126;1236-46; 15131783
Elimination of background recombination: somatic induction of Cre by combined transcriptional regulation and hormone binding affinity.;Kemp Richard, Ireland Heather, Clayton Elizabeth, Houghton Carol, Howard Louise, Winton Douglas J, ;2004;Nucleic acids research;32;e92; 15247325

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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