IMPC phenotypes (allele matching)
C57BL/6N-Latem1(IMPC)Ics/Ics
| Status | Available to order |
| EMMA ID | EM:14897 |
| Citation information | RRID:IMSR_EM:14897 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Latem1(IMPC)Ics/Ics |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Latem1(IMPC)Ics |
| Gene/Transgene symbol | Lat |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to LAT deficiency / Orphanet_504523
MGI phenotypes (gene matching)
- abnormal salivary gland morphology / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- decreased body weight / MGI
- abnormal immune system physiology / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- increased inflammatory response / MGI
- kidney inflammation / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- pancreas inflammation / MGI
- salivary gland inflammation / MGI
- premature death / MGI
- abnormal B cell differentiation / MGI
- abnormal T cell differentiation / MGI
- abnormal lymph organ size / MGI
- abnormal lymph node secondary follicle morphology / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal lymphopoiesis / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T-helper 2 cell morphology / MGI
- abnormal effector T cell morphology / MGI
- abnormal plasma cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell number / MGI
- increased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- increased IgM level / MGI
- increased IgE level / MGI
- chronic inflammation / MGI
- abnormal lymphocyte morphology / MGI
- abnormal immune system organ morphology / MGI
- abnormal immune serum protein physiology / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- pancreas fibrosis / MGI
- increased autoantibody level / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- renal fibrosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- increased susceptibility to autoimmune hemolytic anemia / MGI
- increased anti-chromatin antibody level / MGI
- abnormal T cell selection / MGI
- increased spleen weight / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- decreased T cell number / MGI
- abnormal thrombosis / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal T-helper 2 physiology / MGI
- increased blood urea nitrogen level / MGI
- abnormal T cell morphology / MGI
- increased memory T cell number / MGI
- absent T cells / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased T-helper 2 cell number / MGI
- increased plasma cell number / MGI
- abnormal B cell activation / MGI
- abnormal mature gamma-delta T cell morphology / MGI
- increased mature gamma-delta T cell number / MGI
- absent mature gamma-delta T cells / MGI
- abnormal gamma-delta T cell differentiation / MGI
- increased spleen germinal center number / MGI
- increased IgG1 level / MGI
- abnormal lymph node germinal center morphology / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal T cell receptor gamma chain V-J recombination / MGI
- abnormal T cell receptor delta chain V(D)J recombination / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- abnormal platelet aggregation / MGI
- decreased platelet aggregation / MGI
- phlebitis / MGI
- renal glomerular immunoglobulin deposits / MGI