IMPC phenotypes (allele matching)
C57BL/6N-Latem1(IMPC)Ics/Ics
| Status | Available to order |
| EMMA ID | EM:14897 |
| International strain name | C57BL/6N-Latem1(IMPC)Ics/Ics |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Latem1(IMPC)Ics |
| Gene/Transgene symbol | Lat |
Information from provider
| Provider | ICS, Institut Clinique de la Souris |
| Provider affiliation | ICS, Institut Clinique de la Souris |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | ICS, Institut Clinique de la Souris, Illkirch-Graffenstaden, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to LAT deficiency / Orphanet_504523
MGI phenotypes (gene matching)
- abnormal salivary gland morphology / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- decreased body weight / MGI
- abnormal immune system physiology / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- increased inflammatory response / MGI
- kidney inflammation / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- pancreas inflammation / MGI
- salivary gland inflammation / MGI
- premature death / MGI
- abnormal B cell differentiation / MGI
- abnormal T cell differentiation / MGI
- abnormal lymph organ size / MGI
- abnormal lymph node secondary follicle morphology / MGI
- abnormal spleen white pulp morphology / MGI
- abnormal spleen periarteriolar lymphoid sheath morphology / MGI
- abnormal lymphopoiesis / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- abnormal T-helper 2 cell morphology / MGI
- abnormal effector T cell morphology / MGI
- abnormal plasma cell morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell number / MGI
- increased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- increased IgM level / MGI
- increased IgE level / MGI
- chronic inflammation / MGI
- abnormal lymphocyte morphology / MGI
- abnormal immune system organ morphology / MGI
- abnormal immune serum protein physiology / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- pancreas fibrosis / MGI
- increased autoantibody level / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- renal fibrosis / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- increased susceptibility to autoimmune hemolytic anemia / MGI
- increased anti-chromatin antibody level / MGI
- abnormal T cell selection / MGI
- increased spleen weight / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- decreased T cell number / MGI
- abnormal thrombosis / MGI
- decreased double-negative T cell number / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal T cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- abnormal T-helper 2 physiology / MGI
- increased blood urea nitrogen level / MGI
- abnormal T cell morphology / MGI
- increased memory T cell number / MGI
- absent T cells / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased T-helper 2 cell number / MGI
- increased plasma cell number / MGI
- abnormal B cell activation / MGI
- abnormal mature gamma-delta T cell morphology / MGI
- increased mature gamma-delta T cell number / MGI
- absent mature gamma-delta T cells / MGI
- abnormal gamma-delta T cell differentiation / MGI
- increased spleen germinal center number / MGI
- increased IgG1 level / MGI
- abnormal lymph node germinal center morphology / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-4 secretion / MGI
- abnormal T cell receptor gamma chain V-J recombination / MGI
- abnormal T cell receptor delta chain V(D)J recombination / MGI
- abnormal splenic cell ratio / MGI
- abnormal thymus cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- abnormal platelet aggregation / MGI
- decreased platelet aggregation / MGI
- phlebitis / MGI
- renal glomerular immunoglobulin deposits / MGI