- abnormal stria vascularis morphology / MGI
- increased neutrophil cell number / MGI
- cortical renal glomerulopathies / MGI
- enlarged lymph nodes / MGI
- impaired coordination / MGI
- abnormal spatial learning / MGI
- decreased IgG level / MGI
- conjunctivitis / MGI
- vasculitis / MGI
- salivary gland inflammation / MGI
- premature death / MGI
- abnormal kidney physiology / MGI
- abnormal lymph node morphology / MGI
- increased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- increased IgG level / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- dilated renal glomerular capsule / MGI
- increased autoantibody level / MGI
- abnormal strial intermediate cell morphology / MGI
- abnormal conjunctival epithelium morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal myocardium layer morphology / MGI
- vision/eye phenotype / MGI
- abnormal enzyme/coenzyme activity / MGI
- CNS inflammation / MGI
- increased plasma cell number / MGI
- podocyte foot process effacement / MGI
- decreased marginal zone B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased mature B cell number / MGI
- decreased immature B cell number / MGI
- decreased spleen germinal center number / MGI
- renal glomerulus hypertrophy / MGI
- expanded mesangial matrix / MGI
- mesangial cell hyperplasia / MGI
- glomerular crescent / MGI
- increased or absent threshold for auditory brainstem response / MGI
- abnormal thyroid gland morphology / MGI
- enlarged spleen / MGI
- enlarged thymus / MGI
- skin lesions / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal immune system physiology / MGI
- vascular inflammation / MGI
- abnormal gland morphology / MGI
- abnormal thymus medulla morphology / MGI
- abnormal T cell physiology / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal type III hypersensitivity reaction / MGI
- abnormal immune system organ morphology / MGI
- joint swelling / MGI
- increased circulating serum albumin level / MGI
- thyroid inflammation / MGI
- thymus atrophy / MGI
- abnormal submandibular gland morphology / MGI
- abnormal coronary artery morphology / MGI
- abnormal thyroid follicle morphology / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- abnormal B cell morphology / MGI
- increased thymus weight / MGI
- abnormal cytotoxic T cell physiology / MGI
- abnormal T cell proliferation / MGI
- increased susceptibility to autoimmune disorder / MGI
- endocrine/exocrine gland phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal T-helper 2 physiology / MGI
- increased circulating total protein level / MGI
- abnormal T cell morphology / MGI
- lymph node hyperplasia / MGI
- enlarged Peyer's patches / MGI
- abnormal marginal zone B cell morphology / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin level / MGI
- abnormal B cell receptor editing / MGI
- abnormal lymph node cell ratio / MGI
- submandibular gland inflammation / MGI
- lacrimal gland inflammation / MGI
- abnormal glomerular capillary morphology / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- increased kidney cell proliferation / MGI
- abnormal glomerular capillary endothelium morphology / MGI
- thymus cortex atrophy / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- demyelination / MGI
- focal hepatic necrosis / MGI
- brain inflammation / MGI
- abnormal kidney morphology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- increased anti-histone antibody level / MGI
- increased follicular B cell number / MGI
- increased marginal zone B cell number / MGI
- increased transitional stage B cell number / MGI
- increased immature B cell number / MGI
- decreased B cell apoptosis / MGI
- abnormal splenic cell ratio / MGI
- decreased hepatocyte apoptosis / MGI
- increased splenocyte number / MGI
- abnormal NK cell physiology / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- increased renal glomerulus apoptosis / MGI
- increased spleen weight / MGI
- increased blood urea nitrogen level / MGI
- abnormal airway responsiveness / MGI
- decreased eosinophil cell number / MGI
- immune system phenotype / MGI
- increased apoptosis / MGI
- abnormal B cell activation / MGI
- mortality/aging / MGI
- decreased activated T cell number / MGI
- autoimmune response / MGI
- abnormal leukocyte adhesion / MGI
- decreased B cell number / MGI
- increased double-negative T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal leukocyte morphology / MGI
- impaired leukocyte tethering or rolling / MGI
- ruffled hair / MGI
- increased body weight / MGI
- increased tumor incidence / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal skin condition / MGI
- epidermal necrosis / MGI
- kidney failure / MGI
- decreased neuron apoptosis / MGI
- decreased apoptosis / MGI
- abnormal vagina weight / MGI
- lacrimal gland atrophy / MGI
- cardiovascular system phenotype / MGI
- abnormal stria vascularis vasculature morphology / MGI
- increased susceptibility to type III hypersensitivity reaction / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased macrophage apoptosis / MGI
- increased IgG3 level / MGI
- kidney inflammation / MGI
- increased gamma-delta T cell number / MGI
- abnormal immune system morphology / MGI
MRL/MpJ-Faslpr Mut#/Orl
Status | Under development - register interest |
EMMA ID | EM:14888 |
International strain name | MRL/MpJ-Faslpr Mut#/Orl |
Alternative name | T-lymphocyte deficient MRL/lpr mice |
Strain type | Spontaneous |
Allele/Transgene symbol | Faslpr, Unknown at present |
Gene/Transgene symbol | Fas, Unknown at present |
Information from provider
Provider | Sylviane Muller |
Provider affiliation | UMR7242 Biotechnology and cell signalling, CNRS University of Strasbourg |
Genetic information | T-lymphocyte deficient MRL/lpr mice that derived from the original MRL/lpr strain (MRL/MpJ-Faslpr/J, stock n. 000485); they still possess the MRL and lpr background; whole genomic study not yet available. |
Phenotypic information | Conserved (as in the original MRL/lpr strain): splenomegaly; enlarged lymph nodes and salivary glands; level of serum anti-dsDNA antibodies; peripheral cells of the myeloid lineage (granulocytes and monocytes). Changed in this new mutant strain: milder disease with a reduced proteinuria; decreased count of peripheral cells; decreased number of peripheral cells of the lymphoid lineage (CD4, DC8 and double-negative T cells with alpha/beta and gamma/delta TCR); decrease of activated CD4 T cells. Greater number of births compared to original MRL/lpr mice that usually have 1-2 successive litters of pups only. |
Breeding history | MRL/lpr mice that derived from the original MRL/lpr strain (MRL/MpJ-Faslpr/J, stock n. 000485). They still possess the MRL and lpr background; whole genomic study not yet available. |
References | None available |
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | homozygous MRL/Mp, homozygous MRL/Mp |
Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autoimmune lymphoproliferative syndrome / Orphanet_3261
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal stria vascularis morphology / MGI
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- ruffled hair / MGI
- cortical renal glomerulopathies / MGI
- abnormal hepatocyte morphology / MGI
- abnormal liver physiology / MGI
- abnormal thyroid gland morphology / MGI
- abnormal immune system morphology / MGI
- lymphoid hyperplasia / MGI
- enlarged spleen / MGI
- enlarged lymph nodes / MGI
- enlarged thymus / MGI
- demyelination / MGI
- abnormal skin condition / MGI
- skin lesions / MGI
- epidermal necrosis / MGI
- increased body weight / MGI
- impaired coordination / MGI
- abnormal spatial learning / MGI
- abnormal cardiovascular system physiology / MGI
- abnormal apoptosis / MGI
- focal hepatic necrosis / MGI
- abnormal immune system physiology / MGI
- decreased IgG level / MGI
- abnormal thymus involution / MGI
- decreased activated T cell number / MGI
- autoimmune response / MGI
- brain inflammation / MGI
- conjunctivitis / MGI
- kidney inflammation / MGI
- vascular inflammation / MGI
- vasculitis / MGI
- salivary gland inflammation / MGI
- increased tumor incidence / MGI
- premature death / MGI
- abnormal kidney morphology / MGI
- abnormal kidney physiology / MGI
- abnormal T cell differentiation / MGI
- abnormal hypersensitivity reaction / MGI
- abnormal gland morphology / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph organ size / MGI
- abnormal airway responsiveness / MGI
- abnormal lymph node morphology / MGI
- abnormal thymus medulla morphology / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- increased immunoglobulin level / MGI
- abnormal immunoglobulin level / MGI
- increased IgG level / MGI
- increased IgM level / MGI
- increased IgA level / MGI
- abnormal type III hypersensitivity reaction / MGI
- abnormal immune system organ morphology / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- joint swelling / MGI
- increased urine protein level / MGI
- increased circulating serum albumin level / MGI
- decreased neuron apoptosis / MGI
- thyroid inflammation / MGI
- kidney failure / MGI
- abnormal leukocyte adhesion / MGI
- thymus atrophy / MGI
- dilated renal glomerular capsule / MGI
- increased autoantibody level / MGI
- abnormal submandibular gland morphology / MGI
- abnormal coronary artery morphology / MGI
- abnormal strial intermediate cell morphology / MGI
- abnormal stria vascularis vasculature morphology / MGI
- abnormal conjunctival epithelium morphology / MGI
- abnormal thyroid follicle morphology / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-single stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased anti-histone antibody level / MGI
- increased anti-erythrocyte antigen antibody level / MGI
- increased susceptibility to systemic lupus erythematosus / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal B cell morphology / MGI
- increased spleen weight / MGI
- increased thymus weight / MGI
- abnormal T cell clonal deletion / MGI
- decreased eosinophil cell number / MGI
- increased lymphocyte cell number / MGI
- increased B cell number / MGI
- decreased B cell number / MGI
- increased susceptibility to parasitic infection / MGI
- abnormal cytotoxic T cell physiology / MGI
- increased double-negative T cell number / MGI
- abnormal T cell proliferation / MGI
- liver hyperplasia / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal myocardium layer morphology / MGI
- increased susceptibility to autoimmune disorder / MGI
- endocrine/exocrine gland phenotype / MGI
- cardiovascular system phenotype / MGI
- immune system phenotype / MGI
- vision/eye phenotype / MGI
- abnormal circulating protein level / MGI
- abnormal T-helper 2 physiology / MGI
- increased blood urea nitrogen level / MGI
- increased circulating total protein level / MGI
- abnormal enzyme/coenzyme activity / MGI
- increased susceptibility to type III hypersensitivity reaction / MGI
- increased apoptosis / MGI
- decreased apoptosis / MGI
- CNS inflammation / MGI
- abnormal T cell morphology / MGI
- increased NK cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased plasma cell number / MGI
- lymph node hyperplasia / MGI
- enlarged Peyer's patches / MGI
- podocyte foot process effacement / MGI
- increased follicular B cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- increased marginal zone B cell number / MGI
- decreased marginal zone B cell number / MGI
- increased transitional stage B cell number / MGI
- decreased transitional stage B cell number / MGI
- decreased mature B cell number / MGI
- increased immature B cell number / MGI
- decreased immature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal leukocyte morphology / MGI
- increased gamma-delta T cell number / MGI
- decreased spleen germinal center number / MGI
- increased IgG1 level / MGI
- increased IgG2a level / MGI
- increased IgG2b level / MGI
- increased IgG3 level / MGI
- decreased interleukin-2 secretion / MGI
- abnormal interleukin level / MGI
- abnormal B cell receptor editing / MGI
- decreased B cell apoptosis / MGI
- abnormal splenic cell ratio / MGI
- abnormal lymph node cell ratio / MGI
- submandibular gland inflammation / MGI
- lacrimal gland inflammation / MGI
- decreased hepatocyte apoptosis / MGI
- abnormal vagina weight / MGI
- increased splenocyte number / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- abnormal NK cell physiology / MGI
- mortality/aging / MGI
- decreased macrophage apoptosis / MGI
- renal glomerulus hypertrophy / MGI
- abnormal glomerular capillary morphology / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- expanded mesangial matrix / MGI
- increased renal glomerulus apoptosis / MGI
- renal cast / MGI
- increased renal glomerulus basement membrane thickness / MGI
- mesangial cell hyperplasia / MGI
- increased kidney cell proliferation / MGI
- abnormal glomerular capillary endothelium morphology / MGI
- glomerular crescent / MGI
- increased or absent threshold for auditory brainstem response / MGI
- lacrimal gland atrophy / MGI
- thymus cortex atrophy / MGI
- impaired leukocyte tethering or rolling / MGI
- renal glomerular protein deposits / MGI
- renal glomerular immunoglobulin deposits / MGI
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