IMPC phenotypes (gene matching)
B6Brd;B6N-Tyrc-Brd Lrig1tm1c(EUCOMM)Wtsi/Orl
| Status | Available to order |
| EMMA ID | EM:14884 |
| International strain name | B6Brd;B6N-Tyrc-Brd Lrig1tm1c(EUCOMM)Wtsi/Orl |
| Alternative name | Lrig1tm1c |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lrig1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lrig1 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-CDTA-UAR4 |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0070_3_G09 (Lrig1tm1a(EUCOMM)Wtsi allele). For further details on the construction of this clone see the relevant page at the IMPC portal: https://www.mousephenotype.org/data/alleles/MGI:107935/tm1a(EUCOMM)Wtsi. Rederived tm1a mice have been crossed with flp recombinase deleter mice (EMMA strain EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have been generated. No abnormal phenotype observed.Heterozygous:Nothing observed. |
| Breeding history | Rederived tm1a mice have been crossed with C57BL/6N flp-deleter mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6N Tac |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- distorted hair follicle pattern / MGI
- alopecia / MGI
- thick tail / MGI
- abnormal skin condition / MGI
- scaly skin / MGI
- psoriasis / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- abnormal epidermis stratum basale morphology / MGI
- hyperkeratosis / MGI
- decreased body weight / MGI
- abnormal skin morphology / MGI
- abnormal tail morphology / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal keratinocyte differentiation / MGI
- decreased circulating alanine transaminase level / MGI
- decreased circulating alkaline phosphatase level / MGI
- no phenotypic analysis / MGI
- parakeratosis / MGI
- nervous system phenotype / MGI
- abnormal facial morphology / MGI
- vertebral fusion / MGI
- fusion of vertebral arches / MGI
- abnormal distortion product otoacoustic emission / MGI
- abnormal auditory brainstem response / MGI
- abnormal behavior / MGI
- hearing/vestibular/ear phenotype / MGI
- immune system phenotype / MGI
- decreased circulating aspartate transaminase level / MGI
- abnormal hair shedding / MGI
- increased keratinocyte proliferation / MGI
- decreased total body fat amount / MGI
- abnormal skin adnexa morphology / MGI
- integument phenotype / MGI
- abnormal auditory brainstem response waveform shape / MGI
- increased or absent threshold for auditory brainstem response / MGI