IMPC phenotypes (gene matching)
B6Brd;B6N-Tyrc-Brd Lrig1tm1c(EUCOMM)Wtsi/Orl
| Status | Available to order |
| EMMA ID | EM:14884 |
| Citation information | RRID:IMSR_EM:14884 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6Brd;B6N-Tyrc-Brd Lrig1tm1c(EUCOMM)Wtsi/Orl |
| Alternative name | Lrig1tm1c |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Lrig1tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Lrig1 |
Information from provider
| Provider | Cécile FREMOND |
| Provider affiliation | CNRS-TAAM-CDTA-UAR4 |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0070_3_G09 (Lrig1tm1a(EUCOMM)Wtsi allele). For further details on the construction of this clone see the relevant page at the IMPC portal: https://www.mousephenotype.org/data/alleles/MGI:107935/tm1a(EUCOMM)Wtsi. Rederived tm1a mice have been crossed with flp recombinase deleter mice (EMMA strain EM:05490, C57BL/6NTac-Gt(ROSA)26Sortm2(CAG-flpo,-EYFP)Ics/Ics) to obtain the tm1c allele. |
| Phenotypic information | Homozygous:Homozygous mice have been generated. No abnormal phenotype observed.Heterozygous:Nothing observed. |
| Breeding history | Rederived tm1a mice have been crossed with C57BL/6N flp-deleter mice to obtain the tm1c allele. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | homozygous C57BL/6NTac males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- distorted hair follicle pattern / MGI
- alopecia / MGI
- thick tail / MGI
- abnormal skin condition / MGI
- scaly skin / MGI
- psoriasis / MGI
- thick epidermis / MGI
- epidermal hyperplasia / MGI
- abnormal epidermis stratum basale morphology / MGI
- hyperkeratosis / MGI
- decreased body weight / MGI
- abnormal skin morphology / MGI
- abnormal tail morphology / MGI
- no abnormal phenotype detected / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal keratinocyte differentiation / MGI
- decreased circulating alanine transaminase level / MGI
- decreased circulating alkaline phosphatase level / MGI
- no phenotypic analysis / MGI
- parakeratosis / MGI
- nervous system phenotype / MGI
- abnormal facial morphology / MGI
- vertebral fusion / MGI
- fusion of vertebral arches / MGI
- abnormal distortion product otoacoustic emission / MGI
- abnormal auditory brainstem response / MGI
- abnormal behavior / MGI
- hearing/vestibular/ear phenotype / MGI
- immune system phenotype / MGI
- decreased circulating aspartate transaminase level / MGI
- abnormal hair shedding / MGI
- increased keratinocyte proliferation / MGI
- decreased total body fat amount / MGI
- abnormal skin adnexa morphology / MGI
- integument phenotype / MGI
- abnormal auditory brainstem response waveform shape / MGI
- increased or absent threshold for auditory brainstem response / MGI