B6N.Cg-Acsl4tm1c(EUCOMM)Wtsi/WtsiIegBiat

Status

Available to order

EMMA IDEM:14882
International strain nameB6N.Cg-Acsl4tm1c(EUCOMM)Wtsi/WtsiIegBiat
Alternative nameB6Brd;B6N-Tyrc-Brd Acsl4tm1c(EUCOMM)Wtsi/WtsiIeg
Strain typeTargeted Mutant Strains : Conditional mutation
Allele/Transgene symbolAcsl4tm1c(EUCOMM)Wtsi
Gene/Transgene symbolAcsl4

Information from provider

ProviderMaik Dahlhoff
Provider affiliationDepartment of Biomedical Sciences, University of Veterinary Medicine, Vienna
Genetic informationThis line originates from EMMA strain EM:05887, B6Brd;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/WtsiIeg, EUCOMM ES clone EPD0066_2_D10, after breeding with a flp recombinase deleter line to convert the original tm1a targeted allele (knock-out first allele) into a tm1c conditional allele. For further details on the construction of this clone see this page at the IMPC portal: https://www.mousephenotype.org/data/alleles/MGI:1354713/tm1a(EUCOMM)Wtsi.
Phenotypic informationHomozygous:
no phenotype

Heterozygous:
no phenotype
Breeding history<10 generations backcrossed to C57BL/6N; therefore, agouti pups may appear for a couple of generations.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivingheterozygous C57BL/6NCrlCrlj (Crlj: Charles River Laboratories Japan)
Breeding at archiving centreMice were produced for customer (tm1c allele request).

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased body length / IMPC
  • decreased circulating chloride level / IMPC
  • decreased lean body mass / IMPC
  • lipid deposition / IMPC
  • thrombocytopenia / IMPC
  • abnormal tibia morphology / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased body weight / IMPC
MGI phenotypes (gene matching)
  • abnormal female reproductive system morphology / MGI
  • dilated uterus / MGI
  • decreased body length / MGI
  • reduced female fertility / MGI
  • decreased litter size / MGI
  • increased corpora lutea number / MGI
  • decreased heart weight / MGI
  • thrombocytopenia / MGI
  • decreased lean body mass / MGI
  • enlarged ovary / MGI
  • abnormal endometrium morphology / MGI
  • homeostasis/metabolism phenotype / MGI
  • uterus cysts / MGI
  • abnormal uterus physiology / MGI
  • increased prostaglandin level / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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