IMPC phenotypes (gene matching)
B6N.Cg-Acsl4tm1c(EUCOMM)Wtsi/WtsiIegBiat
| Status | Available to order |
| EMMA ID | EM:14882 |
| Citation information | RRID:IMSR_EM:14882 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6N.Cg-Acsl4tm1c(EUCOMM)Wtsi/WtsiIegBiat |
| Alternative name | B6Brd;B6N-Tyrc-Brd Acsl4tm1c(EUCOMM)Wtsi/WtsiIeg |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Acsl4tm1c(EUCOMM)Wtsi |
| Gene/Transgene symbol | Acsl4 |
Information from provider
| Provider | Maik Dahlhoff |
| Provider affiliation | Department of Biomedical Sciences, University of Veterinary Medicine, Vienna |
| Genetic information | This line originates from EMMA strain EM:05887, B6Brd;B6N-Tyrc-Brd Acsl4tm1a(EUCOMM)Wtsi/WtsiIeg, EUCOMM ES clone EPD0066_2_D10, after breeding with a flp recombinase deleter line to convert the original tm1a targeted allele (knock-out first allele) into a tm1c conditional allele. For further details on the construction of this clone see this page at the IMPC portal: https://www.mousephenotype.org/data/alleles/MGI:1354713/tm1a(EUCOMM)Wtsi. |
| Phenotypic information | Homozygous:no phenotypeHeterozygous:no phenotype |
| Breeding history | <10 generations backcrossed to C57BL/6N; therefore, agouti pups may appear for a couple of generations. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6NCrlCrlj (Crlj: Charles River Laboratories Japan) males |
| Breeding at archiving centre | Mice were produced for customer (tm1c allele request). |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- X-linked non-syndromic intellectual disability / Orphanet_777
MGI phenotypes (gene matching)
- abnormal female reproductive system morphology / MGI
- dilated uterus / MGI
- decreased body length / MGI
- reduced female fertility / MGI
- decreased litter size / MGI
- increased corpora lutea number / MGI
- decreased heart weight / MGI
- thrombocytopenia / MGI
- decreased lean body mass / MGI
- enlarged ovary / MGI
- abnormal endometrium morphology / MGI
- homeostasis/metabolism phenotype / MGI
- uterus cysts / MGI
- abnormal uterus physiology / MGI
- increased prostaglandin level / MGI