C57BL/6NCrl-Clockem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:14845
Citation informationRRID:IMSR_EM:14845 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6NCrl-Clockem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolClockem1(IMPC)Ccpcz
Gene/Transgene symbolClock

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased leukocyte cell number / IMPC
  • abnormal thymus morphology / IMPC
  • enlarged thymus / IMPC
  • increased circulating triglyceride level / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • abnormal skin morphology / IMPC
  • abnormal tooth morphology / IMPC
  • abnormal inspiratory capacity / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased eosinophil cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • decreased heart rate / IMPC
  • decreased circulating serum albumin level / IMPC
  • decreased circulating total protein level / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • decreased red blood cell distribution width / IMPC
  • decreased lung compliance / IMPC
  • increased lung elastance / IMPC
  • increased T-helper cell number / IMPC
  • decreased effector memory T-helper cell number / IMPC
IMPC phenotypes (gene matching)
  • increased leukocyte cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • increased lymphocyte cell number / IMPC
  • abnormal skin morphology / IMPC
  • decreased lung compliance / IMPC
  • abnormal thymus morphology / IMPC
  • decreased circulating total protein level / IMPC
  • decreased heart rate / IMPC
  • increased lung elastance / IMPC
  • increased eosinophil cell number / IMPC
  • decreased red blood cell distribution width / IMPC
  • decreased circulating serum albumin level / IMPC
  • increased T-helper cell number / IMPC
  • decreased effector memory T-helper cell number / IMPC
  • increased CD4-positive, alpha-beta T cell number / IMPC
  • abnormal inspiratory capacity / IMPC
  • increased circulating triglyceride level / IMPC
  • enlarged thymus / IMPC
  • abnormal tooth morphology / IMPC
  • increased circulating HDL cholesterol level / IMPC

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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