C57BL/6NCrl-Tcf3em1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:14816
Citation informationRRID:IMSR_EM:14816 

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International strain nameC57BL/6NCrl-Tcf3em1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolTcf3em1(IMPC)Ccpcz
Gene/Transgene symbolTcf3

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • absent pre-B cells / MGI
  • abnormal cell death / MGI
  • increased cell proliferation / MGI
  • abnormal immune system morphology / MGI
  • enlarged thymus / MGI
  • abnormal lymphocyte cell number / MGI
  • decreased body size / MGI
  • postnatal growth retardation / MGI
  • arrested B cell differentiation / MGI
  • thymus hypoplasia / MGI
  • female infertility / MGI
  • increased T cell derived lymphoma incidence / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal B cell differentiation / MGI
  • no abnormal phenotype detected / MGI
  • abnormal hematopoietic system morphology/development / MGI
  • abnormal lymphopoiesis / MGI
  • abnormal blood cell morphology/development / MGI
  • abnormal B cell number / MGI
  • no phenotypic analysis / MGI
  • nervous system phenotype / MGI
  • spleen atrophy / MGI
  • abnormal T cell subpopulation ratio / MGI
  • abnormal hematopoietic stem cell morphology / MGI
  • increased B cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • increased double-negative T cell number / MGI
  • decreased double-positive T cell number / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • hematopoietic system phenotype / MGI
  • decreased NK cell number / MGI
  • absent B cells / MGI
  • increased single-positive T cell number / MGI
  • decreased dendritic cell number / MGI
  • absent pro-B cells / MGI
  • decreased pro-B cell number / MGI
  • decreased pre-B cell number / MGI
  • abnormal immunoglobulin V(D)J recombination / MGI
  • abnormal immunoglobulin heavy chain V(D)J recombination / MGI
  • abnormal immunoglobulin light chain V-J recombination / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI

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Register interest

Availabilities

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    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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