C57BL/6NCrl-Pik3caem1(IMPC)Ccpcz/Ph

Status

Under development - register interest

EMMA IDEM:14815
International strain nameC57BL/6NCrl-Pik3caem1(IMPC)Ccpcz/Ph
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolPik3caem1(IMPC)Ccpcz
Gene/Transgene symbolPik3ca

Information from provider

Provider Institute of Molecular Genetics
Provider affiliationDepartment of Transgenic Models of Diseases, Institute of Molecular Genetics
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • vasculature congestion / MGI
  • abnormal vascular development / MGI
  • abnormal angiogenesis / MGI
  • decreased cell proliferation / MGI
  • decreased body length / MGI
  • decreased body weight / MGI
  • polyphagia / MGI
  • internal hemorrhage / MGI
  • abnormal somite development / MGI
  • decreased embryo size / MGI
  • pale yolk sac / MGI
  • embryonic growth arrest / MGI
  • postnatal growth retardation / MGI
  • abnormal lymphatic vessel morphology / MGI
  • hemorrhage / MGI
  • neoplasm / MGI
  • increased circulating insulin level / MGI
  • abnormal retinal vasculature morphology / MGI
  • no phenotypic analysis / MGI
  • abnormal vitelline vasculature morphology / MGI
  • increased pancreatic beta cell number / MGI
  • decreased lean body mass / MGI
  • abnormal endocardium morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal vitelline vascular remodeling / MGI
  • fetal growth retardation / MGI
  • decreased incidence of tumors by chemical induction / MGI
  • abnormal anterior cardinal vein morphology / MGI
  • abnormal dorsal aorta morphology / MGI
  • decreased skeletal muscle mass / MGI
  • abnormal brain vasculature morphology / MGI
  • impaired glucose tolerance / MGI
  • insulin resistance / MGI
  • abnormal cell physiology / MGI
  • increased circulating leptin level / MGI
  • increased fat cell size / MGI
  • abnormal lymphangiogenesis / MGI
  • mortality/aging / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • chylous ascites / MGI
  • abnormal intersomitic vessel morphology / MGI
  • abnormal perineural vascular plexus morphology / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

    More details on pricing and delivery times

    Practical information

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

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