RjHan:SD rat Fmr1
| Status | Available to order |
| EMMA ID | EM:14764 |
| International strain name | RjHan:SD rat Fmr1 |
| Alternative name | Fmr1 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Zygote electroporation of gene-specific gRNA and Cas9 was used to ablate specific sequence corresponding to the exon3. |
| Gene/Transgene symbol | Fmr1 |
Information from provider
| Provider | Jana Kopkanova |
| Provider affiliation | Transgenic and Archiving Module, Institute of Molecular Genetics of the Czech Academy of Sciences |
| Genetic information | FMRP translational regulator 1 (FMRP) gene - Mutant rats were generated by zygote electroporation of gene-specific gRNAs (5´-GCAAGAATTGACTACCTCGT-3´ and 5´-GGGGCAAGGGTCTACTAATG-3´) and Cas9 was used to ablate specific sequence corresponding to the exon 3. Such a genomic deletion results in a presumably non-functional protein variant (i.e. gene knock-out) |
| Phenotypic information | Homozygous:not analyzedHeterozygous:not analyzed |
| Breeding history | 2 crossings to RjHan:SD rats |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | wild-type rat Sprague-Dawley, heterozygous rat Sprague-Dawley |
| Stage of embryos | 2-cell |