C57BL/6NTac-Gdf5em1(IMPC)H/H

Status

Available to order

EMMA IDEM:14728
International strain nameC57BL/6NTac-Gdf5em1(IMPC)H/H
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolGdf5em1(IMPC)H
Gene/Transgene symbolGdf5

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • increased bone mineral density / IMPC
  • decreased leukocyte cell number / IMPC
  • abnormal forelimb morphology / IMPC
  • abnormal hindlimb morphology / IMPC
  • abnormal autopod morphology / IMPC
  • decreased locomotor activity / IMPC
  • abnormal gait / IMPC
  • decreased exploration in new environment / IMPC
  • limb grasping / IMPC
  • abnormal digit morphology / IMPC
  • decreased vertical activity / IMPC
  • abnormal bone structure / IMPC
  • decreased lymphocyte cell number / IMPC
IMPC phenotypes (gene matching)
  • abnormal autopod morphology / IMPC
  • abnormal gait / IMPC
  • decreased exploration in new environment / IMPC
  • abnormal digit morphology / IMPC
  • decreased grip strength / IMPC
  • abnormal bone structure / IMPC
  • increased bone mineral density / IMPC
  • abnormal forelimb morphology / IMPC
  • decreased lymphocyte cell number / IMPC
  • decreased leukocyte cell number / IMPC
  • abnormal hindlimb morphology / IMPC
  • decreased locomotor activity / IMPC
  • decreased vertical activity / IMPC
  • limb grasping / IMPC
MGI phenotypes (gene matching)
  • delayed bone ossification / MGI
  • abnormal long bone epiphysis morphology / MGI
  • abnormal cartilage morphology / MGI
  • abnormal cartilage development / MGI
  • decreased chondrocyte number / MGI
  • short limbs / MGI
  • abnormal carpal bone morphology / MGI
  • abnormal tibia morphology / MGI
  • abnormal femur morphology / MGI
  • abnormal autopod morphology / MGI
  • decreased body weight / MGI
  • reduced male fertility / MGI
  • decreased litter size / MGI
  • abnormal limb morphology / MGI
  • abnormal digit morphology / MGI
  • abnormal limb bone morphology / MGI
  • abnormal fibula morphology / MGI
  • disproportionate dwarf / MGI
  • brachyphalangia / MGI
  • brachydactyly / MGI
  • short tibia / MGI
  • short fibula / MGI
  • brachypodia / MGI
  • abnormal long bone epiphyseal plate morphology / MGI
  • abnormal metatarsal bone morphology / MGI
  • abnormal metacarpal bone morphology / MGI
  • short femur / MGI
  • fused joints / MGI
  • delayed endochondral bone ossification / MGI
  • abnormal long bone morphology / MGI
  • short humerus / MGI
  • short radius / MGI
  • short ulna / MGI
  • short metacarpal bones / MGI
  • short metatarsal bones / MGI
  • decreased length of long bones / MGI
  • abnormal tarsal bone morphology / MGI
  • abnormal phalanx morphology / MGI
  • abnormal patella morphology / MGI
  • abnormal limb development / MGI
  • abnormal digit development / MGI
  • abnormal articular cartilage morphology / MGI
  • abnormal endochondral bone ossification / MGI
  • fused phalanges / MGI
  • micromelia / MGI
  • fused carpal bones / MGI
  • decreased birth weight / MGI
  • abnormal limb long bone morphology / MGI
  • joint dislocation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

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Legally binding conditions for the transfer

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