C57BL/6NTac-Sqstm1^em1H/H

Status	Available to order
EMMA ID	EM:14650
Citation information	RRID:IMSR_EM:14650 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Sqstm1^em1H/H
Alternative name	SQSTM1-G331D-EM1-B6N
Strain type	Endonuclease-mediated
Allele/Transgene symbol	Sqstm1^em1H
Gene/Transgene symbol	Sqstm1

Information from provider

Provider	MRC-Harwell
Provider affiliation	Mary Lyon Centre at MRC Harwell
Genetic information	For detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic information	Homozygous: not known Heterozygous: None reported
Breeding history	Co-isogenic on original background
References	None available
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Amyotrophic lateral sclerosis / Orphanet_803
Frontotemporal dementia with motor neuron disease / Orphanet_275872
Behavioral variant of frontotemporal dementia / Orphanet_275864

IMPC phenotypes (gene matching)

increased body length / IMPC
abnormal behavior / IMPC
decreased mean corpuscular hemoglobin / IMPC
decreased circulating glucose level / IMPC
process of degenerative change / IMPC
increased circulating alkaline phosphatase level / IMPC
hypoplasia / IMPC
decreased circulating HDL cholesterol level / IMPC
decreased circulating cholesterol level / IMPC
increased lean body mass / IMPC
decreased circulating LDL cholesterol level / IMPC
decreased mean corpuscular volume / IMPC
decreased hemoglobin content / IMPC

MGI phenotypes (gene matching)

abnormal trabecular bone morphology / MGI
kyphosis / MGI
lordosis / MGI
increased body length / MGI
increased body weight / MGI
abnormal osteoclast physiology / MGI
hyperglycemia / MGI
premature death / MGI
abnormal bone mineralization / MGI
increased susceptibility to age related obesity / MGI
oxidative stress / MGI
premature aging / MGI
abnormal bone structure / MGI
abnormal compact bone morphology / MGI
abnormal behavior / MGI
abnormal osteoclast morphology / MGI
increased osteoclast cell number / MGI
decreased osteoclast cell number / MGI
decreased oxygen consumption / MGI
impaired glucose tolerance / MGI
skeleton phenotype / MGI
decreased circulating glucose level / MGI
decreased mean corpuscular hemoglobin / MGI
increased circulating leptin level / MGI
abnormal mitochondrial physiology / MGI
abnormal bone ossification / MGI
abnormal osteoclast differentiation / MGI
decreased interleukin-6 secretion / MGI
decreased subcutaneous adipose tissue amount / MGI
increased neuron number / MGI
rough coat / MGI
abnormal respiratory electron transport chain / MGI
abnormal aerobic respiration / MGI
increased food intake / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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