IMPC phenotypes (gene matching)
- male infertility / IMPC
C57BL/6NTac-Pla2g6em1H/H
| Status | Available to order |
| EMMA ID | EM:14639 |
| Citation information | RRID:IMSR_EM:14639 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6NTac-Pla2g6em1H/H |
| Alternative name | PLA2G6-R636Q-EM1-B6N |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Pla2g6em1H |
| Gene/Transgene symbol | Pla2g6 |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Infantile neuroaxonal dystrophy / Orphanet_35069
- Adult-onset dystonia-parkinsonism / Orphanet_199351
MGI phenotypes (gene matching)
- kyphosis / MGI
- tremors / MGI
- hindlimb paralysis / MGI
- abnormal spinal cord morphology / MGI
- weight loss / MGI
- ataxia / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased exploration in new environment / MGI
- abnormal motor coordination/balance / MGI
- impaired limb coordination / MGI
- reduced male fertility / MGI
- male infertility / MGI
- blindness / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- abnormal sciatic nerve morphology / MGI
- asthenozoospermia / MGI
- axonal dystrophy / MGI
- abnormal locomotor coordination / MGI
- abnormal nervous system morphology / MGI
- abnormal myelin sheath morphology / MGI
- increased cholesterol level / MGI
- decreased double-positive T cell number / MGI
- abnormal spinal cord ventral horn morphology / MGI
- abnormal brainstem morphology / MGI
- abnormal axon morphology / MGI
- axon degeneration / MGI
- abnormal mitochondrion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal spinal cord grey matter morphology / MGI
- abnormal synaptic bouton morphology / MGI
- abnormal astrocyte physiology / MGI
- skeletal muscle atrophy / MGI
- axonal spheroids / MGI
- decreased grip strength / MGI
- abnormal apolipoprotein level / MGI
- abnormal mitochondrial crista morphology / MGI
- abnormal cell cytoskeleton morphology / MGI