IMPC phenotypes (gene matching)
- male infertility / IMPC
C57BL/6NTac-Pla2g6em1H/H
| Status | Available to order |
| EMMA ID | EM:14639 |
| International strain name | C57BL/6NTac-Pla2g6em1H/H |
| Alternative name | PLA2G6-R636Q-EM1-B6N |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Pla2g6em1H |
| Gene/Transgene symbol | Pla2g6 |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Infantile neuroaxonal dystrophy / Orphanet_35069
- Adult-onset dystonia-parkinsonism / Orphanet_199351
MGI phenotypes (gene matching)
- kyphosis / MGI
- tremors / MGI
- hindlimb paralysis / MGI
- abnormal spinal cord morphology / MGI
- weight loss / MGI
- ataxia / MGI
- hyperactivity / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- increased exploration in new environment / MGI
- abnormal motor coordination/balance / MGI
- impaired limb coordination / MGI
- reduced male fertility / MGI
- male infertility / MGI
- blindness / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- abnormal brain morphology / MGI
- neurodegeneration / MGI
- muscular atrophy / MGI
- abnormal sciatic nerve morphology / MGI
- asthenozoospermia / MGI
- axonal dystrophy / MGI
- abnormal locomotor coordination / MGI
- abnormal nervous system morphology / MGI
- abnormal myelin sheath morphology / MGI
- increased cholesterol level / MGI
- decreased double-positive T cell number / MGI
- abnormal spinal cord ventral horn morphology / MGI
- abnormal brainstem morphology / MGI
- abnormal axon morphology / MGI
- axon degeneration / MGI
- abnormal mitochondrion morphology / MGI
- abnormal brain white matter morphology / MGI
- abnormal spinal cord grey matter morphology / MGI
- abnormal synaptic bouton morphology / MGI
- abnormal astrocyte physiology / MGI
- skeletal muscle atrophy / MGI
- axonal spheroids / MGI
- decreased grip strength / MGI
- abnormal apolipoprotein level / MGI
- abnormal mitochondrial crista morphology / MGI
- abnormal cell cytoskeleton morphology / MGI