C57BL/6NTac-Cdh23ahl+em3H Nefhem1H/H

Status

Available to order

EMMA IDEM:14634
International strain nameC57BL/6NTac-Cdh23ahl+em3H Nefhem1H/H
Alternative nameNEFH-E461K-EM1-B6N-Cdh23
Strain typeEndonuclease-mediated
Allele/Transgene symbolCdh23ahl+em3H, Nefhem1H
Gene/Transgene symbolCdh23, Nefh

Information from provider

Provider MRC-Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (gene matching)
  • decreased circulating calcium level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating alanine transaminase level / IMPC
  • absent pinna reflex / IMPC
  • decreased body length / IMPC
  • decreased circulating glucose level / IMPC
  • increased mean corpuscular hemoglobin / IMPC
  • trunk curl / IMPC
  • increased lean body mass / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating sodium level / IMPC
  • abnormal gait / IMPC
  • impaired righting response / IMPC
  • decreased fasting circulating glucose level / IMPC
  • increased circulating chloride level / IMPC
  • stereotypic behavior / IMPC
  • decreased leukocyte cell number / IMPC
  • increased bone mineral content / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
MGI phenotypes (gene matching)
  • abnormal ear position / MGI
  • abnormal inner ear morphology / MGI
  • abnormal cochlea morphology / MGI
  • abnormal organ of Corti morphology / MGI
  • organ of Corti degeneration / MGI
  • abnormal stria vascularis morphology / MGI
  • tremors / MGI
  • abnormal maternal nurturing / MGI
  • abnormal stationary movement / MGI
  • abnormal locomotor behavior / MGI
  • ataxia / MGI
  • circling / MGI
  • bidirectional circling / MGI
  • hyperactivity / MGI
  • abnormal gait / MGI
  • head bobbing / MGI
  • decreased grooming behavior / MGI
  • abnormal startle reflex / MGI
  • decreased startle reflex / MGI
  • impaired swimming / MGI
  • decreased litter size / MGI
  • abnormal reflex / MGI
  • abnormal hearing physiology / MGI
  • deafness / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • abnormal ear morphology / MGI
  • abnormal cochlear hair cell morphology / MGI
  • head shaking / MGI
  • decreased vertical activity / MGI
  • abnormal cochlear ganglion morphology / MGI
  • cochlear ganglion degeneration / MGI
  • abnormal otolith morphology / MGI
  • abnormal response to novelty / MGI
  • abnormal cochlear sensory epithelium morphology / MGI
  • cochlear ganglion hypoplasia / MGI
  • abnormal defecation / MGI
  • abnormal ear physiology / MGI
  • vestibular saccular degeneration / MGI
  • vestibular saccular macula degeneration / MGI
  • cochlear hair cell degeneration / MGI
  • stria vascularis degeneration / MGI
  • decreased cochlear inner hair cell number / MGI
  • cochlear inner hair cell degeneration / MGI
  • abnormal cochlear outer hair cell morphology / MGI
  • decreased cochlear outer hair cell number / MGI
  • cochlear outer hair cell degeneration / MGI
  • decreased cochlear hair cell number / MGI
  • abnormal cochlear nerve compound action potential / MGI
  • abnormal hair cell mechanoelectric transduction / MGI
  • abnormal cochlear hair cell physiology / MGI
  • abnormal cochlear outer hair cell physiology / MGI
  • abnormal orientation of outer hair cell stereociliary bundles / MGI
  • abnormal orientation of inner hair cell stereociliary bundles / MGI
  • abnormal vestibular hair cell stereociliary bundle morphology / MGI
  • abnormal cochlear hair cell stereociliary bundle morphology / MGI
  • abnormal orientation of cochlear hair cell stereociliary bundles / MGI
  • decreased cochlear hair cell stereocilia number / MGI
  • abnormal outer hair cell stereociliary bundle morphology / MGI
  • decreased outer hair cell stereocilia number / MGI
  • absent outer hair cell stereocilia / MGI
  • abnormal inner hair cell stereociliary bundle morphology / MGI
  • abnormal cochlear hair cell inter-stereocilial links morphology / MGI
  • abnormal cochlear hair bundle tip links morphology / MGI
  • increased susceptibility to noise-induced hearing loss / MGI
  • abnormal distortion product otoacoustic emission / MGI
  • absent distortion product otoacoustic emissions / MGI
  • abnormal auditory brainstem response / MGI
  • abnormal vestibular system physiology / MGI
  • increased susceptibility to age-related hearing loss / MGI
  • absent linear vestibular evoked potential / MGI
  • head tilt / MGI
  • head tossing / MGI
  • novel environmental response-related retropulsion / MGI
  • homeostasis/metabolism phenotype / MGI
  • hearing/vestibular/ear phenotype / MGI
  • behavior/neurological phenotype / MGI
  • vision/eye phenotype / MGI
  • abnormal eye electrophysiology / MGI
  • impaired hearing / MGI
  • absent pinna reflex / MGI
  • absent startle reflex / MGI
  • abnormal inner hair cell kinocilium morphology / MGI
  • abnormal outer hair cell kinocilium morphology / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • decreased a wave implicit time / MGI
  • decreased b wave implicit time / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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