IMPC phenotypes (gene matching)
C57BL/6J-Foxn1em1H/H
| Status | Available to order |
| EMMA ID | EM:14624 |
| International strain name | C57BL/6J-Foxn1em1H/H |
| Alternative name | FOXN1-DELTA550-EM1-B6 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Foxn1em1H |
| Gene/Transgene symbol | Foxn1 |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to FOXN1 deficiency / Orphanet_169095
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- increased granulocyte number / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- underdeveloped hair follicles / MGI
- abnormal nail morphology / MGI
- deformed nails / MGI
- abnormal liver morphology / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal thymus morphology / MGI
- abnormal thymus development / MGI
- athymia / MGI
- small thymus / MGI
- thymus hyperplasia / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal lymphocyte cell number / MGI
- small ovary / MGI
- thin skin / MGI
- wrinkled skin / MGI
- abnormal epidermal layer morphology / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- wavy vibrissae / MGI
- short vibrissae / MGI
- sparse vibrissae / MGI
- absent vibrissae / MGI
- increased incidence of corneal inflammation / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- thymus hypoplasia / MGI
- abnormal T cell activation / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- decreased litter size / MGI
- increased sarcoma incidence / MGI
- abnormal hair growth / MGI
- premature death / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal skin pigmentation / MGI
- abnormal vibrissa morphology / MGI
- abnormal muscle morphology / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node morphology / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- decreased immunoglobulin level / MGI
- asthenozoospermia / MGI
- abnormal immune system organ morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal circulating gonadotropin level / MGI
- abnormal hair follicle development / MGI
- abnormal compact bone morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- abnormal hair cortex morphology / MGI
- hairless / MGI
- brittle hair / MGI
- abnormal venule morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased length of allograft survival / MGI
- decreased skeletal muscle mass / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased T cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-positive T cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- blepharitis / MGI
- ascites / MGI
- endocrine/exocrine gland phenotype / MGI
- immune system phenotype / MGI
- corneal vascularization / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased single-positive T cell number / MGI
- lymph node hypoplasia / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-2 level / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal spleen physiology / MGI
- abnormal splenic cell ratio / MGI
- chromosomal instability / MGI
- coiled sperm flagellum / MGI
- decreased skeletal muscle fiber size / MGI
- abnormal thymus epithelium morphology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal hair cortex keratinization / MGI
- increased DN1 thymic pro-T cell number / MGI
- abnormal circulating cytokine level / MGI
- absent thymus cortex / MGI
- decreased lymphoma incidence / MGI
- increased plasmacytoma incidence / MGI
- abnormal hair follicle bulb morphology / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- integument phenotype / MGI
- postnatal lethality, incomplete penetrance / MGI
- increased or absent threshold for auditory brainstem response / MGI
- impaired spatial learning / MGI
- short nails / MGI
- nail dystrophy / MGI
- abnormal nail plate morphology / MGI
- abnormal nail matrix morphology / MGI
- absent thymus medulla / MGI
- thymus cysts / MGI
- abnormal corneocyte morphology / MGI