IMPC phenotypes (gene matching)
C57BL/6J-Foxn1em1H/H
| Status | Available to order |
| EMMA ID | EM:14624 |
| Citation information | RRID:IMSR_EM:14624 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Foxn1em1H/H |
| Alternative name | FOXN1-DELTA550-EM1-B6 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Foxn1em1H |
| Gene/Transgene symbol | Foxn1 |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Severe combined immunodeficiency due to FOXN1 deficiency / Orphanet_169095
MGI phenotypes (gene matching)
- increased bone mineral density / MGI
- abnormal trabecular bone morphology / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- increased granulocyte number / MGI
- abnormal coat/ hair morphology / MGI
- abnormal hair follicle morphology / MGI
- underdeveloped hair follicles / MGI
- abnormal nail morphology / MGI
- deformed nails / MGI
- abnormal liver morphology / MGI
- abnormal immune system morphology / MGI
- abnormal spleen morphology / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- abnormal Peyer's patch morphology / MGI
- abnormal thymus morphology / MGI
- abnormal thymus development / MGI
- athymia / MGI
- small thymus / MGI
- thymus hyperplasia / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal lymphocyte cell number / MGI
- small ovary / MGI
- thin skin / MGI
- wrinkled skin / MGI
- abnormal epidermal layer morphology / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- wavy vibrissae / MGI
- short vibrissae / MGI
- sparse vibrissae / MGI
- absent vibrissae / MGI
- increased incidence of corneal inflammation / MGI
- postnatal growth retardation / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- thymus hypoplasia / MGI
- abnormal T cell activation / MGI
- reduced male fertility / MGI
- reduced female fertility / MGI
- female infertility / MGI
- abnormal estrous cycle / MGI
- decreased litter size / MGI
- increased sarcoma incidence / MGI
- abnormal hair growth / MGI
- premature death / MGI
- abnormal embryonic tissue morphology / MGI
- abnormal skin pigmentation / MGI
- abnormal vibrissa morphology / MGI
- abnormal muscle morphology / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node morphology / MGI
- abnormal lymph node T cell domain morphology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal CD4-positive, alpha beta T cell morphology / MGI
- decreased immunoglobulin level / MGI
- asthenozoospermia / MGI
- abnormal immune system organ morphology / MGI
- decreased circulating luteinizing hormone level / MGI
- decreased circulating follicle stimulating hormone level / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal circulating gonadotropin level / MGI
- abnormal hair follicle development / MGI
- abnormal compact bone morphology / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair cuticle / MGI
- abnormal hair cortex morphology / MGI
- hairless / MGI
- brittle hair / MGI
- abnormal venule morphology / MGI
- decreased incidence of tumors by chemical induction / MGI
- increased length of allograft survival / MGI
- decreased skeletal muscle mass / MGI
- abnormal CD8-positive, alpha beta T cell morphology / MGI
- increased eosinophil cell number / MGI
- increased B cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased T cell number / MGI
- decreased susceptibility to parasitic infection / MGI
- decreased double-negative T cell number / MGI
- increased double-positive T cell number / MGI
- decreased double-positive T cell number / MGI
- cachexia / MGI
- blepharitis / MGI
- ascites / MGI
- endocrine/exocrine gland phenotype / MGI
- immune system phenotype / MGI
- corneal vascularization / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased single-positive T cell number / MGI
- lymph node hypoplasia / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- decreased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- decreased circulating interleukin-6 level / MGI
- decreased circulating interleukin-2 level / MGI
- reduced hair shaft melanin granule number / MGI
- abnormal spleen physiology / MGI
- abnormal splenic cell ratio / MGI
- chromosomal instability / MGI
- coiled sperm flagellum / MGI
- decreased skeletal muscle fiber size / MGI
- abnormal thymus epithelium morphology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal hair cortex keratinization / MGI
- increased DN1 thymic pro-T cell number / MGI
- abnormal circulating cytokine level / MGI
- absent thymus cortex / MGI
- decreased lymphoma incidence / MGI
- increased plasmacytoma incidence / MGI
- abnormal hair follicle bulb morphology / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- integument phenotype / MGI
- postnatal lethality, incomplete penetrance / MGI
- increased or absent threshold for auditory brainstem response / MGI
- impaired spatial learning / MGI
- short nails / MGI
- nail dystrophy / MGI
- abnormal nail plate morphology / MGI
- abnormal nail matrix morphology / MGI
- absent thymus medulla / MGI
- thymus cysts / MGI
- abnormal corneocyte morphology / MGI