IMPC phenotypes (gene matching)
- decreased leukocyte cell number / IMPC
C57BL/6J-Egfrem1H/H
| Status | Available to order |
| EMMA ID | EM:14619 |
| Citation information | RRID:IMSR_EM:14619 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6J-Egfrem1H/H |
| Alternative name | EGFR-Y1018F-EM1-B6 |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Egfrem1H |
| Gene/Transgene symbol | Egfr |
Information from provider
| Provider | MRC-Harwell |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | For detailed information on the genetic description of this strain, please have a look at this report. |
| Phenotypic information | Homozygous:not knownHeterozygous:None reported |
| Breeding history | Co-isogenic on original background |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Neonatal inflammatory skin and bowel disease / Orphanet_294023
MGI phenotypes (gene matching)
- short mandible / MGI
- cleft palate / MGI
- decreased leukocyte cell number / MGI
- abnormal aorta morphology / MGI
- abnormal myocardial fiber morphology / MGI
- abnormal hair follicle morphology / MGI
- decreased hair follicle number / MGI
- abnormal hair follicle orientation / MGI
- distorted hair follicle pattern / MGI
- increased curvature of hairs / MGI
- increased curvature of guard hairs / MGI
- waved hair / MGI
- alopecia / MGI
- sparse hair / MGI
- short hair / MGI
- delayed hair appearance / MGI
- abnormal hair cycle / MGI
- long snout / MGI
- pointed snout / MGI
- mandible hypoplasia / MGI
- abnormal esophageal epithelium morphology / MGI
- abnormal intestine morphology / MGI
- abnormal colon morphology / MGI
- increased foot pad pigmentation / MGI
- abnormal nail morphology / MGI
- long toenails / MGI
- abnormal liver morphology / MGI
- abnormal hepatocyte morphology / MGI
- abnormal mammary gland morphology / MGI
- abnormal tongue morphology / MGI
- abnormal filiform papillae morphology / MGI
- abnormal tongue epithelium morphology / MGI
- decreased brain size / MGI
- abnormal cerebral cortex morphology / MGI
- abnormal olfactory bulb morphology / MGI
- small cerebellum / MGI
- abnormal cerebellum external granule cell layer morphology / MGI
- decreased Purkinje cell number / MGI
- abnormal dorsal root ganglion morphology / MGI
- abnormal sensory neuron innervation pattern / MGI
- abnormal vagina orifice morphology / MGI
- abnormal lung development / MGI
- atelectasis / MGI
- thick pulmonary interalveolar septum / MGI
- flaky skin / MGI
- thick skin / MGI
- abnormal epidermal layer morphology / MGI
- thin epidermis / MGI
- thick epidermis / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis stratum granulosum morphology / MGI
- abnormal epidermis stratum corneum morphology / MGI
- decreased body weight / MGI
- weight loss / MGI
- decreased body size / MGI
- curly vibrissae / MGI
- wavy vibrissae / MGI
- loss of vibrissae / MGI
- short vibrissae / MGI
- absent vibrissae / MGI
- microphthalmia / MGI
- eyelids open at birth / MGI
- cataract / MGI
- fused cornea and lens / MGI
- corneal opacity / MGI
- corneal scarring / MGI
- abnormal eyelid morphology / MGI
- absent eyelids / MGI
- dehydration / MGI
- abnormal coat appearance / MGI
- disheveled coat / MGI
- cyanosis / MGI
- cardiac hypertrophy / MGI
- abnormal intestinal absorption / MGI
- decreased embryo size / MGI
- abnormal placenta morphology / MGI
- decreased trophoblast giant cell number / MGI
- placental labyrinth hypoplasia / MGI
- abnormal placenta labyrinth morphology / MGI
- postnatal growth retardation / MGI
- abnormal lactation / MGI
- abnormal pancreas morphology / MGI
- respiratory failure / MGI
- respiratory distress / MGI
- abnormal hair growth / MGI
- abnormal hair texture / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal skin pigmentation / MGI
- abnormal vibrissa morphology / MGI
- abnormal fertility/fecundity / MGI
- abnormal outer ear morphology / MGI
- abnormal bronchus morphology / MGI
- abnormal terminal bronchiole morphology / MGI
- abnormal pulmonary alveolus morphology / MGI
- abnormal type II pneumocyte morphology / MGI
- abnormal lung interstitium morphology / MGI
- heart left ventricle hypertrophy / MGI
- increased heart rate / MGI
- abnormal inner cell mass morphology / MGI
- abnormal semilunar valve morphology / MGI
- abnormal aortic valve morphology / MGI
- no phenotypic analysis / MGI
- cardiac fibrosis / MGI
- nervous system phenotype / MGI
- abnormal hair follicle development / MGI
- abnormal hair shaft morphology / MGI
- abnormal hair medulla / MGI
- increased left ventricle systolic pressure / MGI
- dry skin / MGI
- prolonged PR interval / MGI
- abnormal heart left ventricle morphology / MGI
- decreased fetal size / MGI
- small pancreas / MGI
- abnormal maternal decidual layer morphology / MGI
- small placenta / MGI
- dilated kidney collecting duct / MGI
- abnormal trophoblast layer morphology / MGI
- cachexia / MGI
- abnormal pancreatic beta cell morphology / MGI
- abnormal exocrine pancreas morphology / MGI
- growth/size/body region phenotype / MGI
- reproductive system phenotype / MGI
- decreased cornea thickness / MGI
- increased circulating creatinine level / MGI
- increased blood urea nitrogen level / MGI
- decreased ventricle muscle contractility / MGI
- dilated terminal bronchiole tubes / MGI
- impaired lung alveolus development / MGI
- aortic valve regurgitation / MGI
- calcified aortic valve / MGI
- aortic valve stenosis / MGI
- thin cerebral cortex / MGI
- abnormal fungiform papillae morphology / MGI
- increased pulse pressure / MGI
- petechiae / MGI
- hematoma / MGI
- asymmetric snout / MGI
- plush coat / MGI
- disorganized pancreatic islets / MGI
- failure of eyelid fusion / MGI
- decreased embryo weight / MGI
- abnormal eyelid development / MGI
- abnormal hair cortex keratinization / MGI
- abnormal skin appearance / MGI
- rough coat / MGI
- prolonged RR interval / MGI
- increased heart left ventricle size / MGI
- enlarged aortic valve / MGI
- thick aortic valve / MGI
- abnormal hair follicle inner root sheath morphology / MGI
- integument phenotype / MGI
- dilated respiratory conducting tubes / MGI
- decreased alveolar lamellar body number / MGI
- abnormal bronchiole epithelium morphology / MGI
- abnormal pulmonary alveolus epithelium morphology / MGI
- abnormal pulmonary interalveolar septum morphology / MGI
- abnormal pulmonary acinus morphology / MGI
- abnormal branching involved in lung morphogenesis / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality, complete penetrance / MGI
- embryonic lethality at implantation, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- preweaning lethality, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality between implantation and somite formation, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- lethality throughout fetal growth and development, incomplete penetrance / MGI
- decreased fibroblast cell migration / MGI
- enhanced osteoblast differentiation / MGI
- abnormal heart valve physiology / MGI
- increased cardiac stroke volume / MGI
- decreased spongiotrophoblast size / MGI
- abnormal submandibular gland branching morphogenesis / MGI
- premature chondrocyte differentiation / MGI
- small Meckel's cartilage / MGI
- narrow snout / MGI