C57BL/6J-Bach2em1H/H

Status

Available to order

EMMA IDEM:14612
Citation informationRRID:IMSR_EM:14612 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6J-Bach2em1H/H
Alternative nameBACH2-G26K-EM1-B6
Strain typeEndonuclease-mediated
Allele/Transgene symbolBach2em1H
Gene/Transgene symbolBach2

Information from provider

Provider MRC-Harwell
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationFor detailed information on the genetic description of this strain, please have a look at this report.
Phenotypic informationHomozygous:
not known

Heterozygous:
None reported
Breeding historyCo-isogenic on original background
ReferencesNone available
Homozygous fertilenot known
Homozygous viablenot known
Homozygous matings requirednot known
Immunocompromisednot known

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased KLRG1-positive NK cell number / IMPC
  • decreased mature B cell number / IMPC
  • abnormal optic disk morphology / IMPC
  • increased monocyte cell number / IMPC
  • increased KLRG1+ CD4 alpha-beta T cell number / IMPC
  • decreased transitional stage B cell number / IMPC
  • increased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased effector memory CD8-positive, alpha-beta T cell number / IMPC
  • decreased circulating creatinine level / IMPC
  • increased pulmonary respiratory rate / IMPC
  • increased KLRG1+ CD8 alpha-beta T cell number / IMPC
  • hyperactivity / IMPC
  • increased effector memory T-helper cell number / IMPC
  • decreased regulatory T cell number / IMPC
  • increased eosinophil cell number / IMPC
  • decreased memory-marker CD4-negative NK T cell number / IMPC
  • decreased food intake / IMPC
  • increased CD4-positive, alpha-beta memory T cell number / IMPC
  • increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • decreased B cell number / IMPC
  • increased neutrophil cell number / IMPC
  • increased memory-marker CD4-negative NK T cell number / IMPC
  • decreased CD4-negative NK T cell number / IMPC
  • increased NK cell number / IMPC
  • increased memory-marker NK cell number / IMPC
  • increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number / IMPC
  • immune system phenotype / IMPC
  • decreased Ly6C-positive immature NK cell number / IMPC
  • increased circulating alkaline phosphatase level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased B-1a cell number / IMPC
  • decreased follicular B cell number / IMPC
  • increased CD8-positive, alpha-beta memory T cell number / IMPC
  • decreased exploration in new environment / IMPC
  • short tibia / IMPC
  • increased circulating amylase level / IMPC
  • increased CD11b-low dendritic cell number / IMPC
  • increased KLRG1-positive CD4-negative NK T cell number / IMPC
  • increased grip strength / IMPC
  • decreased CD11b-high dendritic cell number / IMPC
  • increased KLRG1-positive gamma-delta T cell number / IMPC
  • increased NK T cell number / IMPC
  • decreased bone mineral density / IMPC
  • decreased vertical activity / IMPC
  • limb grasping / IMPC
  • decreased prepulse inhibition / IMPC
  • increased CD103-positive CD11b-low dendritic cell number / IMPC
  • increased granulocyte number / IMPC
  • increased Ly6C low monocyte number / IMPC
  • decreased CD8-positive, naive alpha-beta T cell number / IMPC
  • increased circulating iron level / IMPC
  • increased Ly6C high monocyte number / IMPC
  • decreased marginal zone B cell number / IMPC
  • increased macrophage cell number / IMPC
  • decreased respiratory quotient / IMPC
  • decreased memory-marker NK cell number / IMPC
  • increased circulating aspartate transaminase level / IMPC
  • thrombocytosis / IMPC
  • decreased Ly6C-positive mature NK cell number / IMPC
  • increased immature B cell number / IMPC
  • decreased NK T cell number / IMPC
  • increased circulating unsaturated transferrin level / IMPC
  • decreased B-2 B cell number / IMPC
  • decreased bone mineral content / IMPC
  • abnormal bone structure / IMPC
MGI phenotypes (gene matching)
  • spleen hypoplasia / MGI
  • decreased IgG level / MGI
  • decreased IgA level / MGI
  • abnormal B cell differentiation / MGI
  • abnormal B cell physiology / MGI
  • increased IgM level / MGI
  • abnormal somatic hypermutation frequency / MGI
  • abnormal class switch recombination / MGI
  • decreased B cell number / MGI
  • absent germinal center B cells / MGI
  • decreased marginal zone B cell number / MGI
  • decreased mature B cell number / MGI
  • increased immature B cell number / MGI
  • decreased IgG1 level / MGI
  • decreased IgG2a level / MGI
  • decreased IgG2b level / MGI
  • decreased IgG3 level / MGI
  • myeloid hyperplasia / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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