C57BL/6N-Chd1em1(IMPC)Wtsi/WtsiPh

Status

Available to order

EMMA IDEM:14543
International strain nameC57BL/6N-Chd1em1(IMPC)Wtsi/WtsiPh
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolChd1em1(IMPC)Wtsi
Gene/Transgene symbolChd1

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Intellectual disability-autism-speech apraxia-craniofacial dysmorphism syndrome / Orphanet_529965
IMPC phenotypes (gene matching)
  • abnormal eye morphology / IMPC
  • decreased mean corpuscular hemoglobin concentration / IMPC
  • preweaning lethality, complete penetrance / IMPC
  • increased grip strength / IMPC
  • decreased red blood cell distribution width / IMPC
  • embryonic lethality prior to organogenesis / IMPC
  • abnormal embryo size / IMPC
  • anophthalmia / IMPC
  • embryonic lethality prior to tooth bud stage / IMPC
  • abnormal tooth morphology / IMPC
  • abnormal maxilla morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal embryo development / MGI
  • abnormal mesoderm development / MGI
  • failure to gastrulate / MGI
  • decreased embryo size / MGI
  • abnormal developmental patterning / MGI
  • no abnormal phenotype detected / MGI
  • absent extraembryonic ectoderm / MGI
  • no phenotypic analysis / MGI
  • abnormal cell cycle / MGI
  • abnormal rostral-caudal axis patterning / MGI
  • embryonic lethality, complete penetrance / MGI
  • small embryonic epiblast / MGI
  • increased embryonic epiblast cell apoptosis / MGI
  • absent anterior visceral endoderm / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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