C57BL/6N-A^tm1Brd Coro1c^{tm1a(KOMP)Wtsi}/WtsiOulu

Status	Available to order
EMMA ID	EM:14530
International strain name	C57BL/6N-A^tm1Brd Coro1c^{tm1a(KOMP)Wtsi}/WtsiOulu
Alternative name	EPD0343_2_A06
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Coro1c^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Coro1c
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0343_2_A06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland

Disease and phenotype information

IMPC phenotypes (allele matching)

increased erythrocyte cell number / IMPC
decreased mean corpuscular hemoglobin / IMPC

IMPC phenotypes (gene matching)

increased erythrocyte cell number / IMPC
decreased mean corpuscular hemoglobin / IMPC

MGI phenotypes (allele matching)

abnormal interatrial septum morphology / MGI
enlarged liver sinusoidal spaces / MGI
abnormal forebrain morphology / MGI
abnormal third ventricle morphology / MGI
exencephaly / MGI
small superior cervical ganglion / MGI
abnormal ovary morphology / MGI
dilated bile duct / MGI
epididymal cyst / MGI
abnormal eye muscle morphology / MGI
basisphenoid bone foramen / MGI
abnormal viscerocranium morphology / MGI
abnormal cervical rib / MGI
abnormal cystic duct morphology / MGI
decreased parotid gland size / MGI
abnormal inferior vena cava valve morphology / MGI
subcutaneous edema / MGI
abnormal vitelline vein connection / MGI
absent ductus venosus valve / MGI
multiple persisting craniopharyngeal ducts / MGI
blood in lymph vessels / MGI
abnormal coronary sinus connection / MGI
abnormal vertebral artery topology / MGI
embryo tumor / MGI
heterochrony / MGI

MGI phenotypes (gene matching)

abnormal interatrial septum morphology / MGI
enlarged liver sinusoidal spaces / MGI
abnormal forebrain morphology / MGI
abnormal third ventricle morphology / MGI
exencephaly / MGI
small superior cervical ganglion / MGI
abnormal ovary morphology / MGI
no abnormal phenotype detected / MGI
dilated bile duct / MGI
epididymal cyst / MGI
abnormal eye muscle morphology / MGI
basisphenoid bone foramen / MGI
abnormal viscerocranium morphology / MGI
abnormal cervical rib / MGI
abnormal cystic duct morphology / MGI
decreased parotid gland size / MGI
abnormal inferior vena cava valve morphology / MGI
subcutaneous edema / MGI
abnormal vitelline vein connection / MGI
absent ductus venosus valve / MGI
multiple persisting craniopharyngeal ducts / MGI
blood in lymph vessels / MGI
abnormal coronary sinus connection / MGI
abnormal vertebral artery topology / MGI
embryo tumor / MGI
heterochrony / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

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C57BL/6N-Atm1Brd Coro1ctm1a(KOMP)Wtsi/WtsiOulu