IMPC phenotypes (allele matching)
C57BL/6N-Arid1btm1b(EUCOMM)Hmgu/WtsiPh
| Status | Available to order |
| EMMA ID | EM:14526 |
| International strain name | C57BL/6N-Arid1btm1b(EUCOMM)Hmgu/WtsiPh |
| Alternative name | HEPD0532_6_C10 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Arid1btm1b(EUCOMM)Hmgu |
| Gene/Transgene symbol | Arid1b |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from EUCOMM ES clone HEPD0532_6_C10. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on EUCOMM final vectors. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Coffin-Siris syndrome / Orphanet_1465
IMPC phenotypes (gene matching)
- abnormal spleen morphology / IMPC
- decreased prepulse inhibition / IMPC
- preweaning lethality, complete penetrance / IMPC
- decreased locomotor activity / IMPC
- impaired cued conditioning behavior / IMPC
- edema / IMPC
- male infertility / IMPC
- increased circulating creatinine level / IMPC
- increased freezing behavior / IMPC
- abnormal freezing behavior / IMPC
- decreased exploration in new environment / IMPC
- decreased fasting circulating glucose level / IMPC
- preweaning lethality, incomplete penetrance / IMPC
MGI phenotypes (gene matching)
- muscle weakness / MGI
- decreased corpus callosum size / MGI
- abnormal dentate gyrus morphology / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased anxiety-related response / MGI
- increased grooming behavior / MGI
- abnormal vocalization / MGI
- postnatal growth retardation / MGI
- abnormal homeostasis / MGI
- hydroencephaly / MGI
- small heart / MGI
- decreased heart weight / MGI
- small kidney / MGI
- decreased kidney weight / MGI
- decreased circulating insulin-like growth factor I level / MGI
- behavior/neurological phenotype / MGI
- abnormal hypothalamus physiology / MGI
- thin cerebral cortex / MGI
- abnormal insulin-like growth factor I level / MGI
- decreased neuron number / MGI
- decreased birth body size / MGI
- decreased grip strength / MGI
- perinatal lethality, complete penetrance / MGI
- decreased dentate gyrus size / MGI
- abnormal response to social novelty / MGI
- decreased cerebral cortex cell number / MGI