C57BL/6N-Atm1Brd Unktm1a(KOMP)Wtsi/WtsiBiat

Status

Available to order

EMMA IDEM:14478
International strain nameC57BL/6N-Atm1Brd Unktm1a(KOMP)Wtsi/WtsiBiat
Alternative nameEPD0704_5_D04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolUnktm1a(KOMP)Wtsi
Gene/Transgene symbolUnk
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0704_5_D04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Veterinary Medicine, Vienna, Austria
Animals used for archivingheterozygous C57BL/6N-A/a
Breeding at archiving centreSperm was frozen and tested at Sanger and shipped to Vetmeduni in Dec 2015

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased body length / IMPC
  • increased erythrocyte cell number / IMPC
  • decreased mean corpuscular hemoglobin / IMPC
  • increased grip strength / IMPC
  • increased bone mineral content / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • decreased mean corpuscular hemoglobin / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased erythrocyte cell number / IMPC
  • increased bone mineral content / IMPC
  • increased grip strength / IMPC
  • decreased body length / IMPC
MGI phenotypes (allele matching)
  • absent kidney / MGI
  • small superior cervical ganglion / MGI
  • absent ureter / MGI
  • decreased parotid gland size / MGI
  • fused right lung lobes / MGI
  • absent hypoglossal nerve / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • abnormal carotid artery origin / MGI
MGI phenotypes (gene matching)
  • absent kidney / MGI
  • small superior cervical ganglion / MGI
  • absent ureter / MGI
  • decreased parotid gland size / MGI
  • fused right lung lobes / MGI
  • absent hypoglossal nerve / MGI
  • absent segment of posterior cerebral artery / MGI
  • subcutaneous edema / MGI
  • hemangioma / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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