IMPC phenotypes (allele matching)
C57BL/6N-Irf6em1(IMPC)Wtsi/WtsiCnbc
| Status | Available to order |
| EMMA ID | EM:14435 |
| International strain name | C57BL/6N-Irf6em1(IMPC)Wtsi/WtsiCnbc |
| Alternative name | |
| Strain type | Endonuclease-mediated |
| Allele/Transgene symbol | Irf6em1(IMPC)Wtsi |
| Gene/Transgene symbol | Irf6 |
Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6N |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant popliteal pterygium syndrome / Orphanet_1300
- Oligodontia / Orphanet_99798
- Van der Woude syndrome / Orphanet_888
MGI phenotypes (gene matching)
- delayed bone ossification / MGI
- cleft palate / MGI
- abnormal tooth development / MGI
- decreased hair follicle number / MGI
- abnormal cranium morphology / MGI
- short snout / MGI
- abnormal mouth morphology / MGI
- abnormal jaw morphology / MGI
- abnormal esophagus morphology / MGI
- short limbs / MGI
- abnormal forelimb morphology / MGI
- abnormal hindlimb morphology / MGI
- syndactyly / MGI
- synostosis / MGI
- short tail / MGI
- abnormal tongue morphology / MGI
- shiny skin / MGI
- tight skin / MGI
- abnormal epidermal layer morphology / MGI
- thick epidermis / MGI
- abnormal epidermis stratum basale morphology / MGI
- abnormal epidermis suprabasal layer morphology / MGI
- abnormal epidermis stratum spinosum morphology / MGI
- absent epidermis stratum corneum / MGI
- absent vibrissae / MGI
- abnormal digit morphology / MGI
- abnormal craniofacial bone morphology / MGI
- abnormal keratinocyte morphology / MGI
- abnormal keratinocyte differentiation / MGI
- curly tail / MGI
- abnormal esophagus development / MGI
- abnormal craniofacial development / MGI
- abnormal skin development / MGI
- short sternum / MGI
- absent presphenoid bone / MGI
- abnormal palatine bone horizontal plate morphology / MGI
- small mandible / MGI
- abnormal mandibular angle morphology / MGI
- small vertebrae / MGI
- split xiphoid process / MGI
- decreased length of long bones / MGI
- abnormal phalanx morphology / MGI
- abnormal incisor morphology / MGI
- craniofacial phenotype / MGI
- abnormal skeleton morphology / MGI
- absent outer ear / MGI
- abnormal digit development / MGI
- fused phalanges / MGI
- delayed skin barrier formation / MGI
- absent epidermis stratum granulosum / MGI
- increased keratinocyte proliferation / MGI
- abnormal palate development / MGI
- palatal shelf fusion with tongue or mandible / MGI
- failure of palatal shelf elevation / MGI
- cleft secondary palate / MGI
- postnatal lethality, complete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- abnormal periderm development / MGI
- abnormal oral cavity morphology / MGI
- round snout / MGI