C57BL/6N-Hipk3em1(IMPC)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:14433
International strain nameC57BL/6N-Hipk3em1(IMPC)Wtsi/WtsiCnbc
Alternative name
Strain typeEndonuclease-mediated
Allele/Transgene symbolHipk3em1(IMPC)Wtsi
Gene/Transgene symbolHipk3

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from CRISPR zygote microinjection. For further details see the project page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivingheterozygous C57BL/6N

Disease and phenotype information

IMPC phenotypes (gene matching)
  • decreased locomotor activity / IMPC
  • decreased prepulse inhibition / IMPC
  • increased fasting circulating glucose level / IMPC
  • abnormal auditory brainstem response / IMPC
  • decreased heart rate / IMPC
  • prolonged RR interval / IMPC
  • decreased startle reflex / IMPC
  • increased heart rate variability / IMPC
  • increased circulating alanine transaminase level / IMPC
  • increased mean platelet volume / IMPC
  • thrombocytosis / IMPC
MGI phenotypes (gene matching)
  • decreased insulin secretion / MGI
  • abnormal pancreatic beta cell physiology / MGI
  • abnormal pancreatic islet morphology / MGI
  • impaired glucose tolerance / MGI
  • homeostasis/metabolism phenotype / MGI
  • small pancreatic islets / MGI
  • decreased pancreatic beta cell proliferation / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable), as well as a CRISPR surcharge.

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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