- increased circulating insulin level / IMPC
- decreased lean body mass / IMPC
- increased mean corpuscular hemoglobin / IMPC
- increased blood urea nitrogen level / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
- absent pinna reflex / IMPC
- increased total body fat amount / IMPC
- increased red blood cell distribution width / IMPC
C57BL/6N-Kmt2etm1.2(IMPC)Wtsi/WtsiOrl
Status | Available to order |
EMMA ID | EM:14411 |
Citation information | RRID:IMSR_EM:14411 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
International strain name | C57BL/6N-Kmt2etm1.2(IMPC)Wtsi/WtsiOrl |
Alternative name | BEPD0111_B03 |
Strain type | |
Allele/Transgene symbol | Kmt2etm1.2(IMPC)Wtsi |
Gene/Transgene symbol | Kmt2e |
Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
Provider | Wellcome Trust Sanger Institute |
Provider affiliation | Wellcome Trust Sanger Institute |
Genetic information | This mouse line originates from undef ES clone BEPD0111_B03. For further details on the construction of this clone see the page at the IMPC portal. ES cells were generated using the CRISPR/Cas9 technology. The details of the applied experimental procedures involving CRISPR/Cas9 technology are not available. |
Phenotypic information | Potential phenotyping data in the IMPC portal |
References | None available |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Non-specific syndromic intellectual disability / Orphanet_528084
IMPC phenotypes (allele matching)
IMPC phenotypes (gene matching)
- decreased lean body mass / IMPC
- increased total body fat amount / IMPC
- absent pinna reflex / IMPC
- increased circulating insulin level / IMPC
- increased mean corpuscular hemoglobin / IMPC
- increased red blood cell distribution width / IMPC
- increased blood urea nitrogen level / IMPC
- increased mean corpuscular hemoglobin concentration / IMPC
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- small spleen / MGI
- spleen hypoplasia / MGI
- small thymus / MGI
- decreased thymocyte number / MGI
- decreased body weight / MGI
- decreased body size / MGI
- increased mortality induced by gamma-irradiation / MGI
- postnatal growth retardation / MGI
- thymus hypoplasia / MGI
- reduced female fertility / MGI
- male infertility / MGI
- abnormal definitive hematopoiesis / MGI
- small lymph nodes / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal lymphopoiesis / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal myeloblast morphology/development / MGI
- abnormal neutrophil differentiation / MGI
- abnormal neutrophil physiology / MGI
- low mean erythrocyte cell number / MGI
- globozoospermia / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- no phenotypic analysis / MGI
- thrombocytopenia / MGI
- decreased macrophage cell number / MGI
- abnormal hematopoietic stem cell morphology / MGI
- increased hematopoietic stem cell number / MGI
- decreased hematopoietic stem cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- decreased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- blepharitis / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased NK T cell number / MGI
- decreased NK cell number / MGI
- abnormal granulocyte differentiation / MGI
- decreased pro-B cell number / MGI
- decreased pre-B cell number / MGI
- decreased common myeloid progenitor cell number / MGI
- increased hemoglobin concentration distribution width / MGI
- decreased total body fat amount / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, incomplete penetrance / MGI
- lethality during fetal growth through weaning, incomplete penetrance / MGI
- dilated seminal vesicles / MGI
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