C57BL/6N-A^tm1Brd Dynll1^{tm1(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:14354
International strain name	C57BL/6N-A^tm1Brd Dynll1^{tm1(KOMP)Wtsi}/WtsiH
Alternative name	EPD0397_1_B02
Strain type
Allele/Transgene symbol	Dynll1^{tm1(KOMP)Wtsi}
Gene/Transgene symbol	Dynll1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0397_1_B02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

increased circulating alkaline phosphatase level / IMPC
increased circulating bilirubin level / IMPC
decreased circulating glucose level / IMPC
decreased circulating fructosamine level / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

increased circulating alkaline phosphatase level / IMPC
increased circulating bilirubin level / IMPC
preweaning lethality, complete penetrance / IMPC
decreased circulating fructosamine level / IMPC
decreased circulating glucose level / IMPC

MGI phenotypes (gene matching)

dextrocardia / MGI
exencephaly / MGI
absent lungs / MGI
microphthalmia / MGI
edema / MGI
no abnormal phenotype detected / MGI
left pulmonary isomerism / MGI
small lung / MGI
interrupted aortic arch / MGI
coloboma / MGI
abnormal cardiac outflow tract development / MGI
right-sided stomach / MGI
decreased embryonic cilium length / MGI
abnormal primary cilium morphology / MGI
abnormal embryonic neuroepithelium primary cilium morphology / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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