C57BL/6N-1700007K13Riktm2b(EUCOMM)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:14313
International strain nameC57BL/6N-1700007K13Riktm2b(EUCOMM)Wtsi/WtsiH
Alternative nameEPD0968_5_H07
Strain typeTargeted Mutant Strains
Allele/Transgene symbol1700007K13Riktm2b(EUCOMM)Wtsi
Gene/Transgene symbol1700007K13Rik
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0968_5_H07. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using a cell permeable HTN-Cre as described in doi:10.1007/s11248-013-9764-x. Click here for more information on EUCOMM final vectors.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

MGI phenotypes (allele matching)
  • muscular ventricular septal defect / MGI
  • abnormal aortic valve cusp morphology / MGI
  • situs inversus totalis / MGI
  • absent segment of posterior cerebral artery / MGI
  • retropleural edema / MGI
  • blood in lymph vessels / MGI
  • abnormal vertebral artery topology / MGI
  • heterochrony / MGI
MGI phenotypes (gene matching)
  • abnormal heart morphology / MGI
  • abnormal mitral valve morphology / MGI
  • right pulmonary isomerism / MGI
  • dextrocardia / MGI
  • mesocardia / MGI
  • abnormal spleen morphology / MGI
  • abnormal left-right axis patterning / MGI
  • abnormal kidney morphology / MGI
  • no abnormal phenotype detected / MGI
  • persistent truncus arteriosis / MGI
  • heart hypoplasia / MGI
  • dilated heart atrium / MGI
  • left pulmonary isomerism / MGI
  • abnormal heart left ventricle morphology / MGI
  • abnormal primitive node morphology / MGI
  • heterotaxia / MGI
  • abnormal liver lobule morphology / MGI
  • abnormal lateral plate mesoderm morphology / MGI
  • ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • abnormal aortic valve cusp morphology / MGI
  • right-sided stomach / MGI
  • abnormal lung position or orientation / MGI
  • abnormal lung lobe morphology / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • situs inversus totalis / MGI
  • absent segment of posterior cerebral artery / MGI
  • retropleural edema / MGI
  • blood in lymph vessels / MGI
  • abnormal vertebral artery topology / MGI
  • heterochrony / MGI
  • left sided inferior vena cava / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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