IMPC phenotypes (gene matching)
- decreased mean corpuscular hemoglobin concentration / IMPC
NOD.B6-Prf1tm1Sdz/Cnrm
| Status | Available to order |
| EMMA ID | EM:00143 |
| International strain name | NOD.B6-Prf1tm1Sdz/Cnrm |
| Alternative name | Pfp-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Prf1tm1Sdz |
| Gene/Transgene symbol | Prf1 |
Information from provider
| Provider | Hans Hengartner |
| Provider affiliation | Institute of Experimental Immunology, Institute of Experimental Immunology |
| Phenotypic information | Functional inactivation of the perforin gene. Animals show a strong reduction in cell-mediated cytotoxicity of both T- and NK-origin. Activation and proliferation of T-cells is unaffected. Impaired cytotoxicity by T- and NK-cells. Model for insulin-dependent Diabetes Mellitus (now referred to as Type I Diabetes). |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI allele-associated human disease models
Orphanet associated rare diseases, based on orthologous gene matching
- Fatal post-viral neurodegenerative disorder / Orphanet_391343
- Familial hemophagocytic lymphohistiocytosis / Orphanet_540
MGI phenotypes (allele matching)
- insulitis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- periinsulitis / MGI
- increased incidence of induced tumors / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- decreased leukocyte cell number / MGI
- decreased neutrophil cell number / MGI
- decreased bone marrow cell number / MGI
- ruffled hair / MGI
- demyelination / MGI
- weight loss / MGI
- hypoactivity / MGI
- hunched posture / MGI
- increased circulating triglyceride level / MGI
- abnormal body temperature homeostasis / MGI
- abnormal T cell activation / MGI
- brain inflammation / MGI
- liver inflammation / MGI
- abnormal lymph node morphology / MGI
- abnormal spleen white pulp morphology / MGI
- increased susceptibility to viral infection / MGI
- decreased erythrocyte cell number / MGI
- thrombocytopenia / MGI
- lymph node inflammation / MGI
- abnormal lymphocyte physiology / MGI
- abnormal behavior / MGI
- abnormal cytotoxic T cell physiology / MGI
- decreased cytotoxic T cell cytolysis / MGI
- pancytopenia / MGI
- lethargy / MGI
- increased circulating aspartate transaminase level / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- decreased body temperature / MGI
- CNS inflammation / MGI
- increased spleen red pulp amount / MGI
- increased circulating tumor necrosis factor level / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interferon-alpha level / MGI
- increased circulating interferon-gamma level / MGI
- increased circulating interleukin-10 level / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- decreased NK cell degranulation / MGI
- abnormal brain meninges morphology / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- abnormal circulating cytokine level / MGI
- abnormal circulating fibrinogen level / MGI
- abnormal macrophage activation involved in immune response / MGI
- increased circulating lactate dehydrogenase level / MGI
- abnormal inflammatory response / MGI
- increased B cell derived lymphoma incidence / MGI
- premature death / MGI
- increased susceptibility to infection / MGI
- increased susceptibility to bacterial infection / MGI
- abnormal leukocyte physiology / MGI
- abnormal female reproductive system physiology / MGI
- increased susceptibility to parasitic infection / MGI
- increased interleukin-10 secretion / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- decreased tumor latency / MGI
- abnormal NK cell physiology / MGI
- increased lymphoma incidence / MGI
- abnormal circulating glucose level / MGI
- decreased pancreatic beta cell number / MGI
- increased physiological sensitivity to xenobiotic / MGI
- increased T cell derived lymphoma incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased sarcoma incidence / MGI
- abnormal tumor morphology / MGI
- increased tumor latency / MGI
MGI phenotypes (gene matching)
- abnormal circulating glucose level / MGI
- decreased leukocyte cell number / MGI
- decreased neutrophil cell number / MGI
- decreased bone marrow cell number / MGI
- ruffled hair / MGI
- demyelination / MGI
- weight loss / MGI
- hypoactivity / MGI
- hunched posture / MGI
- increased circulating triglyceride level / MGI
- abnormal body temperature homeostasis / MGI
- abnormal T cell activation / MGI
- increased activated T cell number / MGI
- abnormal inflammatory response / MGI
- brain inflammation / MGI
- liver inflammation / MGI
- increased incidence of induced tumors / MGI
- increased B cell derived lymphoma incidence / MGI
- increased T cell derived lymphoma incidence / MGI
- increased lung adenocarcinoma incidence / MGI
- increased sarcoma incidence / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal lymph node morphology / MGI
- abnormal spleen white pulp morphology / MGI
- increased susceptibility to infection / MGI
- decreased susceptibility to bacterial infection / MGI
- increased susceptibility to bacterial infection / MGI
- increased susceptibility to viral infection / MGI
- abnormal leukocyte physiology / MGI
- decreased erythrocyte cell number / MGI
- decreased circulating alanine transaminase level / MGI
- abnormal cytokine secretion / MGI
- thrombocytopenia / MGI
- decreased pancreatic beta cell number / MGI
- abnormal tumor morphology / MGI
- abnormal female reproductive system physiology / MGI
- increased tumor growth/size / MGI
- lymph node inflammation / MGI
- abnormal lymphocyte physiology / MGI
- insulitis / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- abnormal behavior / MGI
- increased susceptibility to parasitic infection / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- abnormal cytotoxic T cell physiology / MGI
- decreased cytotoxic T cell cytolysis / MGI
- pancytopenia / MGI
- lethargy / MGI
- increased circulating aspartate transaminase level / MGI
- behavior/neurological phenotype / MGI
- immune system phenotype / MGI
- decreased body temperature / MGI
- periinsulitis / MGI
- CNS inflammation / MGI
- decreased T cell apoptosis / MGI
- increased spleen red pulp amount / MGI
- increased circulating tumor necrosis factor level / MGI
- increased tumor necrosis factor secretion / MGI
- increased interferon-gamma secretion / MGI
- decreased interferon-gamma secretion / MGI
- increased circulating interferon-alpha level / MGI
- increased circulating interferon-gamma level / MGI
- increased circulating interleukin-10 level / MGI
- increased circulating interleukin-6 level / MGI
- increased circulating interleukin-18 level / MGI
- increased circulating interleukin-1 beta level / MGI
- increased interleukin-10 secretion / MGI
- decreased NK cell degranulation / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal brain meninges morphology / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased susceptibility to viral infection induced morbidity/mortality / MGI
- increased tumor latency / MGI
- abnormal circulating cytokine level / MGI
- abnormal circulating fibrinogen level / MGI
- decreased tumor latency / MGI
- abnormal NK cell physiology / MGI
- abnormal macrophage activation involved in immune response / MGI
- increased circulating lactate dehydrogenase level / MGI
- increased lymphoma incidence / MGI
Literature references
- Reduced incidence and delayed onset of diabetes in perforin-deficient nonobese diabetic mice.;Kägi D, Odermatt B, Seiler P, Zinkernagel R M, Mak T W, Hengartner H, ;1997;The Journal of experimental medicine;186;989-97; 9314549