C.Cg-Tg(Tcrb-LMR16.2)1Nglh/Orl

Status	Available to order
EMMA ID	EM:01423
Citation information	RRID:IMSR_EM:01423 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C.Cg-Tg(Tcrb-LMR16.2)1Nglh/Orl
Alternative name	16.2 beta
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Tcrb-LMR16.2)1Nglh
Gene/Transgene symbol	Tg(Tcrb-LMR16.2)1Nglh

Information from provider

Provider	Nicolas Glaichenhaus
Provider affiliation	INSERM U561 - Hopital Saint Vincent de Paul, Paris
Genetic information	Mice were made transgenic for a T-cell receptor directed to an antigen (Leishmania activated c kinase: LACK) from the Leishmania parasite.
Phenotypic information	These mice provide a good model to study leishmaniasis since the frequency of CD4+ T cells recognizing an antigen (LACK) from the Leishmania parasite is increased up to 1%. With this frequency, it is possible to follow the immune response to the parasite in both resistant (B10D2) and susceptible (BALB/c) strains.
Breeding history	The mice were backcrossed for 10 generations to the susceptible BALB/c and to the resistant B10D2 background.
References	Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.;Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig K, Guéry J C, Glaichenhaus N, ;2000;Immunity;13;771-82; 11163193 Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells.;Moro Monica, Filippi Christophe, Gallard Alexandra, Malherbe Laurent, Foucras Gilles, Akiba Hisaya, Yagita Hideo, Guéry Jean-Charles, Glaichenhaus Nicolas, ;2002;European journal of immunology;32;3566-75; 12516542

Information from EMMA

Archiving centre	Institut de Transgenose, INTRAGENE, Orléans, France

Literature references

Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major.;Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig K, Guéry J C, Glaichenhaus N, ;2000;Immunity;13;771-82; 11163193
Blockade of CD86 in BALB/c mice infected with Leishmania major does not prevent the expansion of low avidity T cells.;Moro Monica, Filippi Christophe, Gallard Alexandra, Malherbe Laurent, Foucras Gilles, Akiba Hisaya, Yagita Hideo, Guéry Jean-Charles, Glaichenhaus Nicolas, ;2002;European journal of immunology;32;3566-75; 12516542

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

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