C57BL/6N-Cpgi5563tm1.1(NCC)WCS/WtsiIeg

Status

Available to order

EMMA IDEM:14208
International strain nameC57BL/6N-Cpgi5563tm1.1(NCC)WCS/WtsiIeg
Alternative nameEPD01018_3_B07
Strain type
Allele/Transgene symbolCpgi5563tm1.1(NCC)WCS
Gene/Transgene symbolCpgi5563
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from undef ES clone EPD01018_3_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating LDL cholesterol level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • increased body length / IMPC
  • decreased circulating triglyceride level / IMPC
  • decreased circulating free fatty acids level / IMPC
  • increased circulating chloride level / IMPC
  • decreased circulating glycerol level / IMPC
  • increased lean body mass / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating glucose level / IMPC
  • decreased blood urea nitrogen level / IMPC
  • decreased circulating total protein level / IMPC
  • decreased circulating amylase level / IMPC
  • decreased total body fat amount / IMPC
  • increased circulating magnesium level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased fasting circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • decreased fasting circulating glucose level / IMPC
  • increased body length / IMPC
  • increased lean body mass / IMPC
  • decreased circulating glycerol level / IMPC
  • increased circulating chloride level / IMPC
  • decreased circulating total protein level / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • decreased blood urea nitrogen level / IMPC
  • decreased circulating amylase level / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating LDL cholesterol level / IMPC
  • decreased circulating triglyceride level / IMPC
  • increased circulating magnesium level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • decreased circulating glucose level / IMPC
  • decreased total body fat amount / IMPC
  • decreased circulating free fatty acids level / IMPC

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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