C57BL/6N-Adamts3^{tm1b(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:14183
International strain name	C57BL/6N-Adamts3^{tm1b(KOMP)Wtsi}/WtsiH
Alternative name	EPD0660_2_C10
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Adamts3^{tm1b(KOMP)Wtsi}
Gene/Transgene symbol	Adamts3
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0660_2_C10. For further details on the construction of this clone see the page at the IMPC portal. The critical exon(s) were flanked by loxP sites, and subsequent cre expression excised this critical sequence resulting in a knockout reporter allele using an X-linked CMV-Cre driver (EM:05414; C57BL/6N-Hprt^{tm1(CMV-cre)Wtsi}/WtsiOulu) for this purpose. Click here for more information on KOMP final vectors.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Hennekam syndrome / Orphanet_2136

IMPC phenotypes (allele matching)

preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

preweaning lethality, complete penetrance / IMPC

MGI phenotypes (allele matching)

cleft palate / MGI
double outlet right ventricle / MGI
abnormal forebrain morphology / MGI
abnormal lateral ventricle morphology / MGI
abnormal third ventricle morphology / MGI
abnormal fourth ventricle morphology / MGI
abnormal hindbrain morphology / MGI
aorta coarctation / MGI
bifid ureter / MGI
dilated ureter / MGI
abnormal Mullerian duct morphology / MGI
abnormal Wolffian duct morphology / MGI
abnormal adenohypophysis morphology / MGI
basisphenoid bone foramen / MGI
fusion of vertebral arches / MGI
absent stapedial artery / MGI
hemopericardium / MGI
abnormal cervical rib / MGI
thoracoschisis / MGI
abnormal liver parenchyma morphology / MGI
abnormal optic chiasm morphology / MGI
perimembraneous ventricular septal defect / MGI
abnormal vertebral artery morphology / MGI
dual inferior vena cava / MGI
abnormal basilar artery morphology / MGI
absent segment of anterior cerebral artery / MGI
retropleural edema / MGI
subcutaneous edema / MGI
abnormal Mullerian duct topology / MGI
abnormal vitelline vein connection / MGI
trigeminal neuroma / MGI
absent ductus venosus valve / MGI
abnormal ductus venosus valve morphology / MGI
abnormal ductus venosus valve topology / MGI
multiple persisting craniopharyngeal ducts / MGI
abnormal vitelline vein topology / MGI
persistent dorsal ophthalmic artery / MGI
embryo cyst / MGI
heterochrony / MGI

MGI phenotypes (gene matching)

cleft palate / MGI
double outlet right ventricle / MGI
small liver / MGI
abnormal forebrain morphology / MGI
abnormal lateral ventricle morphology / MGI
abnormal third ventricle morphology / MGI
abnormal fourth ventricle morphology / MGI
abnormal hindbrain morphology / MGI
abnormal placenta labyrinth morphology / MGI
skin edema / MGI
abnormal erythrocyte morphology / MGI
liver degeneration / MGI
aorta coarctation / MGI
bifid ureter / MGI
dilated ureter / MGI
pallor / MGI
abnormal Mullerian duct morphology / MGI
abnormal Wolffian duct morphology / MGI
increased hepatocyte apoptosis / MGI
abnormal adenohypophysis morphology / MGI
basisphenoid bone foramen / MGI
fusion of vertebral arches / MGI
absent stapedial artery / MGI
hemopericardium / MGI
skeleton phenotype / MGI
abnormal lymphangiogenesis / MGI
abnormal cervical rib / MGI
thoracoschisis / MGI
abnormal liver parenchyma morphology / MGI
abnormal optic chiasm morphology / MGI
absent lymphatic vessels / MGI
perimembraneous ventricular septal defect / MGI
lethality throughout fetal growth and development, complete penetrance / MGI
abnormal vertebral artery morphology / MGI
abnormal placenta fetal blood space morphology / MGI
dual inferior vena cava / MGI
abnormal basilar artery morphology / MGI
absent segment of anterior cerebral artery / MGI
retropleural edema / MGI
subcutaneous edema / MGI
abnormal Mullerian duct topology / MGI
abnormal vitelline vein connection / MGI
trigeminal neuroma / MGI
absent ductus venosus valve / MGI
abnormal ductus venosus valve morphology / MGI
abnormal ductus venosus valve topology / MGI
multiple persisting craniopharyngeal ducts / MGI
abnormal vitelline vein topology / MGI
persistent dorsal ophthalmic artery / MGI
embryo cyst / MGI
heterochrony / MGI
hemangioma / MGI
abnormal brain artery topology / MGI
persistent trigeminal artery / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Example health report
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Material Transfer Agreement (MTA)
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EMMA conditions
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C57BL/6N-Adamts3tm1b(KOMP)Wtsi/WtsiH