C57BL/6N-A^tm1Brd Glg1^{tm1a(KOMP)Wtsi}/WtsiPh

Status	Under development - register interest
EMMA ID	EM:14122
International strain name	C57BL/6N-A^tm1Brd Glg1^{tm1a(KOMP)Wtsi}/WtsiPh
Alternative name	EPD0269_2_C07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Glg1^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Glg1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0269_2_C07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Institute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)

increased circulating triglyceride level / IMPC
increased circulating glycerol level / IMPC
abnormal vertebral arch morphology / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

increased circulating triglyceride level / IMPC
increased circulating glycerol level / IMPC
preweaning lethality, incomplete penetrance / IMPC
abnormal vertebral arch morphology / IMPC

MGI phenotypes (gene matching)

cleft palate / MGI
decreased body weight / MGI
decreased body size / MGI
abnormal skeleton physiology / MGI
abnormal tail morphology / MGI
abnormal caudal vertebrae morphology / MGI
abnormal leukocyte adhesion / MGI
abnormal bone structure / MGI
abnormal intervertebral disk morphology / MGI
decreased fetal size / MGI
abnormal maxillary shelf morphology / MGI
cardiovascular system phenotype / MGI
decreased long bone epiphyseal plate size / MGI
decreased survivor rate / MGI
meteorism / MGI
decreased fetal weight / MGI
decreased birth body size / MGI
abnormal chondrocyte physiology / MGI
abnormal cellular extravasation / MGI
small thoracic cage / MGI
postnatal lethality, incomplete penetrance / MGI
embryonic lethality, complete penetrance / MGI
enhanced leukocyte tethering or rolling / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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