C57BL/6N-Atm1Brd Glg1tm1a(KOMP)Wtsi/WtsiPh

Status

Under development - register interest

EMMA IDEM:14122
Citation informationRRID:IMSR_EM:14122 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Glg1tm1a(KOMP)Wtsi/WtsiPh
Alternative nameEPD0269_2_C07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolGlg1tm1a(KOMP)Wtsi
Gene/Transgene symbolGlg1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0269_2_C07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic

Disease and phenotype information

IMPC phenotypes (allele matching)
  • increased circulating triglyceride level / IMPC
  • increased circulating glycerol level / IMPC
  • abnormal vertebral arch morphology / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • increased circulating triglyceride level / IMPC
  • increased circulating glycerol level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal vertebral arch morphology / IMPC
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal skeleton physiology / MGI
  • abnormal tail morphology / MGI
  • abnormal caudal vertebrae morphology / MGI
  • abnormal leukocyte adhesion / MGI
  • abnormal bone structure / MGI
  • abnormal intervertebral disk morphology / MGI
  • decreased fetal size / MGI
  • abnormal maxillary shelf morphology / MGI
  • cardiovascular system phenotype / MGI
  • decreased long bone epiphyseal plate size / MGI
  • decreased survivor rate / MGI
  • meteorism / MGI
  • decreased fetal weight / MGI
  • decreased birth body size / MGI
  • abnormal chondrocyte physiology / MGI
  • abnormal cellular extravasation / MGI
  • small thoracic cage / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • embryonic lethality, complete penetrance / MGI
  • enhanced leukocyte tethering or rolling / MGI

Information on how we integrate external resources can be found here

Register interest

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

    Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

    * In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

    More details on pricing and delivery times

    Practical information

    Genotyping protocol

    Example health report
    (Current health report will be provided later)

    Material Transfer Agreement (MTA)
    Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

    EMMA conditions
    Legally binding conditions for the transfer

    Other EMMA strains

    Not found what you were looking for? Search here for other strains available from EMMA.


    Search
    INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).