B6.129-Pax8^tm1Pgr/Cnrm

Status	Available to order
EMMA ID	EM:00141
International strain name	B6.129-Pax8^tm1Pgr/Cnrm
Alternative name	Pax8-KO
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Pax8^tm1Pgr
Gene/Transgene symbol	Pax8

Information from provider

Provider	Peter Gruss
Provider affiliation	Max Planck Inst. Biophysical Chemistry
Phenotypic information	By analysis of Pax8-/- mice, it was demonstrated that Pax8 is required for the formation of the follicular cells in the thyroid. Pax8 is necessary for providing cues for the differentiation of competent endoderm primordia into thyroxin-producing follicular cells.
Breeding history	Backcrossed to C57BL/6 (more than 10 generations)
References	Follicular cells of the thyroid gland require Pax8 gene function.;Mansouri A, Chowdhury K, Gruss P, ;1998;Nature genetics;19;87-90; 9590297

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI allele-associated human disease models

congenital hypothyroidism / DOID:0050328

Orphanet associated rare diseases, based on orthologous gene matching

Athyreosis / Orphanet_95713
Thyroid ectopia / Orphanet_95712
Thyroid hypoplasia / Orphanet_95720

MGI phenotypes (allele matching)

increased circulating thyroid-stimulating hormone level / MGI
delayed bone ossification / MGI
decreased bone mineral density / MGI
decreased compact bone thickness / MGI
short limbs / MGI
abnormal bone remodeling / MGI
delayed endochondral bone ossification / MGI
increased thyroid-stimulating hormone level / MGI
abnormal epiphyseal plate morphology / MGI
abnormal bone trabecula morphology / MGI
decreased bone volume / MGI
decreased femur compact bone thickness / MGI
decreased bone mineral density of femur / MGI
decreased bone mineralization / MGI
small ears / MGI
abnormal organ of Corti morphology / MGI
abnormal middle ear morphology / MGI
abnormal thyroid gland morphology / MGI
uterus hypoplasia / MGI
dilated uterine cervix / MGI
vagina atresia / MGI
arrest of spermatogenesis / MGI
postnatal growth retardation / MGI
male infertility / MGI
female infertility / MGI
deafness / MGI
premature death / MGI
abnormal outer ear morphology / MGI
abnormal cochlear hair cell morphology / MGI
abnormal caput epididymis morphology / MGI
abnormal corpus epididymis morphology / MGI
small thyroid gland / MGI
testicular atrophy / MGI
abnormal thyroid gland development / MGI
abnormal uterus development / MGI
abnormal pillar cell morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal adenohypophysis morphology / MGI
cochlear outer hair cell degeneration / MGI
abnormal cochlear inner hair cell physiology / MGI
abnormal cochlear hair cell stereociliary bundle morphology / MGI
abnormal outer hair cell stereociliary bundle morphology / MGI
abnormal inner hair cell synaptic ribbon morphology / MGI
enlarged tectorial membrane / MGI
abnormal cochlear IHC efferent innervation pattern / MGI
absent thyroid follicular cells / MGI
abnormal thyroid diverticulum morphology / MGI
delayed inner ear development / MGI
abnormal stapedial artery morphology / MGI
absent stapedial artery / MGI
absent epididymis / MGI
absent efferent ductules of testis / MGI
decreased testis weight / MGI
small epididymis / MGI
abnormal epididymis epithelium morphology / MGI
abnormal middle ear ossicle morphology / MGI
abnormal stapes morphology / MGI
abnormal action potential / MGI
decreased circulating thyroxine level / MGI
decreased circulating triiodothyronine level / MGI
absent outer ear / MGI
abnormal external auditory canal morphology / MGI
thin myometrium / MGI
decreased somatotroph cell number / MGI
decreased lactotroph cell number / MGI
increased thyrotroph cell number / MGI
dilated oviduct / MGI
absent uterine horn / MGI
absent endometrium / MGI
abnormal kinocilium morphology / MGI
lethality at weaning, complete penetrance / MGI
postnatal lethality, complete penetrance / MGI
increased or absent threshold for auditory brainstem response / MGI
abnormal auditory bulla morphology / MGI
abnormal stapes crus morpholgy / MGI
small round window / MGI
absent round window / MGI

MGI phenotypes (gene matching)

small ears / MGI
abnormal organ of Corti morphology / MGI
abnormal middle ear morphology / MGI
delayed bone ossification / MGI
decreased bone mineral density / MGI
decreased compact bone thickness / MGI
short limbs / MGI
abnormal thyroid gland morphology / MGI
uterus hypoplasia / MGI
dilated uterine cervix / MGI
vagina atresia / MGI
arrest of spermatogenesis / MGI
postnatal growth retardation / MGI
male infertility / MGI
female infertility / MGI
deafness / MGI
premature death / MGI
no abnormal phenotype detected / MGI
abnormal outer ear morphology / MGI
abnormal cochlear hair cell morphology / MGI
abnormal caput epididymis morphology / MGI
abnormal corpus epididymis morphology / MGI
small thyroid gland / MGI
abnormal bone remodeling / MGI
no phenotypic analysis / MGI
testicular atrophy / MGI
delayed endochondral bone ossification / MGI
abnormal thyroid gland development / MGI
abnormal uterus development / MGI
abnormal pillar cell morphology / MGI
abnormal Mullerian duct morphology / MGI
abnormal adenohypophysis morphology / MGI
cochlear outer hair cell degeneration / MGI
abnormal cochlear inner hair cell physiology / MGI
abnormal cochlear hair cell stereociliary bundle morphology / MGI
abnormal outer hair cell stereociliary bundle morphology / MGI
abnormal inner hair cell synaptic ribbon morphology / MGI
enlarged tectorial membrane / MGI
abnormal cochlear IHC efferent innervation pattern / MGI
absent thyroid follicular cells / MGI
abnormal thyroid diverticulum morphology / MGI
delayed inner ear development / MGI
abnormal stapedial artery morphology / MGI
absent stapedial artery / MGI
absent epididymis / MGI
absent efferent ductules of testis / MGI
decreased testis weight / MGI
small epididymis / MGI
abnormal epididymis epithelium morphology / MGI
abnormal middle ear ossicle morphology / MGI
abnormal stapes morphology / MGI
increased circulating thyroid-stimulating hormone level / MGI
increased thyroid-stimulating hormone level / MGI
absent thyroid gland / MGI
abnormal action potential / MGI
decreased circulating thyroxine level / MGI
decreased circulating triiodothyronine level / MGI
absent outer ear / MGI
abnormal external auditory canal morphology / MGI
abnormal epiphyseal plate morphology / MGI
thin myometrium / MGI
decreased somatotroph cell number / MGI
decreased lactotroph cell number / MGI
increased thyrotroph cell number / MGI
dilated oviduct / MGI
absent uterine horn / MGI
absent endometrium / MGI
abnormal bone trabecula morphology / MGI
decreased bone volume / MGI
abnormal kinocilium morphology / MGI
lethality at weaning, complete penetrance / MGI
postnatal lethality, complete penetrance / MGI
increased or absent threshold for auditory brainstem response / MGI
decreased femur compact bone thickness / MGI
decreased bone mineral density of femur / MGI
decreased bone mineralization / MGI
abnormal auditory bulla morphology / MGI
abnormal stapes crus morpholgy / MGI
small round window / MGI
absent round window / MGI

Literature references

Follicular cells of the thyroid gland require Pax8 gene function.;Mansouri A, Chowdhury K, Gruss P, ;1998;Nature genetics;19;87-90; 9590297

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.129-Pax8tm1Pgr/Cnrm