C57BL/6N-Atm1Brd Il10rbtm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:14098
International strain nameC57BL/6N-Atm1Brd Il10rbtm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0331_6_A08
Strain typeTargeted Mutant Strains
Allele/Transgene symbolIl10rbtm1a(KOMP)Wtsi
Gene/Transgene symbolIl10rb
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0331_6_A08. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Immune dysregulation-inflammatory bowel disease-arthritis-recurrent infections syndrome / Orphanet_238569
IMPC phenotypes (allele matching)
  • decreased circulating glucose level / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating glucose level / IMPC
MGI phenotypes (gene matching)
  • increased leukocyte cell number / MGI
  • extramedullary hematopoiesis / MGI
  • abnormal large intestine morphology / MGI
  • abnormal crypts of Lieberkuhn morphology / MGI
  • abnormal spleen morphology / MGI
  • spleen hyperplasia / MGI
  • colitis / MGI
  • decreased hemoglobin content / MGI
  • large intestinal inflammation / MGI
  • increased spleen weight / MGI
  • abnormal mesenteric lymph node morphology / MGI
  • abnormal granulocyte differentiation / MGI
  • increased interferon-gamma secretion / MGI
  • increased interleukin-17 secretion / MGI
  • abnormal lymph node medullary cord morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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