B6Dnk;B6N-Baz1btm2a(KOMP)Wtsi/WtsiPh

Status

Available to order

EMMA IDEM:14083
International strain nameB6Dnk;B6N-Baz1btm2a(KOMP)Wtsi/WtsiPh
Alternative nameEPD0013_1_C02
Strain typeTargeted Mutant Strains
Allele/Transgene symbolBaz1btm2a(KOMP)Wtsi
Gene/Transgene symbolBaz1b
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0013_1_C02. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreInstitute of Molecular Genetics, Prague, Czech Republic
Animals used for archivingheterozygous C57BL/6NTac

Disease and phenotype information

IMPC phenotypes (allele matching)
  • decreased circulating HDL cholesterol level / IMPC
  • decreased body weight / IMPC
  • abnormal startle reflex / IMPC
  • increased circulating chloride level / IMPC
  • decreased circulating cholesterol level / IMPC
  • decreased circulating total protein level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
IMPC phenotypes (gene matching)
  • decreased circulating cholesterol level / IMPC
  • decreased body weight / IMPC
  • decreased circulating HDL cholesterol level / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • increased circulating chloride level / IMPC
  • abnormal startle reflex / IMPC
  • decreased circulating total protein level / IMPC
MGI phenotypes (gene matching)
  • short mandible / MGI
  • malocclusion / MGI
  • increased circulating calcium level / MGI
  • abnormal heart morphology / MGI
  • double outlet right ventricle / MGI
  • short snout / MGI
  • mandible hypoplasia / MGI
  • decreased body size / MGI
  • decreased litter size / MGI
  • postnatal lethality / MGI
  • abnormal myocardial trabeculae morphology / MGI
  • dilated heart left ventricle / MGI
  • dilated heart right ventricle / MGI
  • aorta coarctation / MGI
  • decreased fetal size / MGI
  • small parietal bone / MGI
  • short nasal bone / MGI
  • abnormal palatine bone morphology / MGI
  • abnormal myocardium layer morphology / MGI
  • cellular phenotype / MGI
  • upturned snout / MGI
  • decreased birth body size / MGI
  • atrial septal defect / MGI
  • muscular ventricular septal defect / MGI
  • increased heart right ventricle size / MGI
  • increased heart left ventricle size / MGI
  • abnormal double-strand DNA break repair / MGI
  • postnatal lethality, complete penetrance / MGI
  • fourth pharyngeal arch hypoplasia / MGI
  • prominent forehead / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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