C57BL/6NTac-Sec23a^{tm1a(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:14078
International strain name	C57BL/6NTac-Sec23a^{tm1a(KOMP)Wtsi}/WtsiH
Alternative name	EPD0072_1_B09
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Sec23a^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Sec23a
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0072_1_B09. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Craniolenticulosutural dysplasia / Orphanet_50814

IMPC phenotypes (allele matching)

decreased total body fat amount / IMPC
process of degenerative change / IMPC
developmental dysplasia / IMPC

IMPC phenotypes (gene matching)

process of degenerative change / IMPC
developmental dysplasia / IMPC
decreased total body fat amount / IMPC

MGI phenotypes (allele matching)

decreased total body fat amount / MGI

MGI phenotypes (gene matching)

abnormal cartilage development / MGI
exencephaly / MGI
open neural tube / MGI
abnormal telencephalon development / MGI
decreased embryo size / MGI
abnormal visceral yolk sac morphology / MGI
intracranial hemorrhage / MGI
abnormal brain morphology / MGI
abnormal extraembryonic tissue physiology / MGI
abnormal amnion morphology / MGI
decreased total body fat amount / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
collapsed brain ventricles / MGI
decreased embryonic neuroepithelial cell proliferation / MGI
small brain ventricles / MGI
abnormal collagen level / MGI
increased endoplasmic reticulum stress / MGI
increased amnion apoptosis / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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