C57BL/6N-Atm1Brd Mto1tm1a(EUCOMM)Wtsi/WtsiOulu

Status

Available to order

EMMA IDEM:14063
International strain nameC57BL/6N-Atm1Brd Mto1tm1a(EUCOMM)Wtsi/WtsiOulu
Alternative nameEPD0431_2_B10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMto1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolMto1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0431_2_B10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreUniversity of Oulu, Oulu, Finland

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

    • Mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency / Orphanet_314637
MGI phenotypes (gene matching)
  • decreased body weight / MGI
  • decreased anxiety-related response / MGI
  • hyperactivity / MGI
  • impaired coordination / MGI
  • decreased startle reflex / MGI
  • abnormal motor coordination/balance / MGI
  • irregular heartbeat / MGI
  • increased heart weight / MGI
  • prolonged QT interval / MGI
  • abnormal response to novel object / MGI
  • dilated sarcoplasmic reticulum / MGI
  • myocardial fiber degeneration / MGI
  • dilated heart / MGI
  • cardiomyopathy / MGI
  • decreased heart rate / MGI
  • abnormal mitochondrial physiology / MGI
  • increased physiological sensitivity to xenobiotic / MGI
  • ventricular premature beat / MGI
  • increased sensitivity to xenobiotic induced morbidity/mortality / MGI
  • abnormal behavioral response to anesthetic / MGI
  • increased grip strength / MGI
  • prolonged QRS complex duration / MGI
  • decreased QRS amplitude / MGI
  • atrioventricular block / MGI
  • sinoatrial block / MGI
  • cardiac muscle necrosis / MGI
  • abnormal mitochondrial inner membrane morphology / MGI
  • decreased mitochondrial DNA content / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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