C57BL/6N-A^tm1Brd Wdr37^{tm1a(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:14052
Citation information	RRID:IMSR_EM:14052 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6N-A^tm1Brd Wdr37^{tm1a(KOMP)Wtsi}/WtsiH
Alternative name	EPD0531_5_A05
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Wdr37^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Wdr37
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0531_5_A05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

kyphosis / IMPC
increased circulating calcium level / IMPC
decreased leukocyte cell number / IMPC
increased circulating insulin level / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal spine curvature / IMPC
vertebral fusion / IMPC
fusion of vertebral arches / IMPC
decreased grip strength / IMPC
increased bone mineral content / IMPC
hyperplasia / IMPC
extramedullary hemopoiesis / IMPC

IMPC phenotypes (gene matching)

hyperplasia / IMPC
increased circulating calcium level / IMPC
increased circulating insulin level / IMPC
decreased grip strength / IMPC
kyphosis / IMPC
increased circulating alkaline phosphatase level / IMPC
abnormal spine curvature / IMPC
extramedullary hemopoiesis / IMPC
vertebral fusion / IMPC
increased bone mineral content / IMPC
fusion of vertebral arches / IMPC
decreased leukocyte cell number / IMPC

MGI phenotypes (allele matching)

decreased body weight / MGI

MGI phenotypes (gene matching)

decreased body weight / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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