C57BL/6NTac-Mybphl^{tm1a(KOMP)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:14044
Citation information	RRID:IMSR_EM:14044 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Mybphl^{tm1a(KOMP)Wtsi}/WtsiH
Alternative name	EPD0108_2_C06
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Mybphl^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Mybphl
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from KOMP ES clone EPD0108_2_C06. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

decreased grip strength / IMPC
preweaning lethality, incomplete penetrance / IMPC

IMPC phenotypes (gene matching)

decreased grip strength / IMPC
preweaning lethality, incomplete penetrance / IMPC

MGI phenotypes (allele matching)

abnormal forebrain morphology / MGI
abnormal lens morphology / MGI
hemorrhage / MGI
aphakia / MGI
abnormal eye muscle morphology / MGI
abnormal optic stalk morphology / MGI
abnormal optic cup morphology / MGI
fusion of vertebral arches / MGI
abnormal optic chiasm morphology / MGI
blood in lymph vessels / MGI
abnormal vertebral artery topology / MGI

MGI phenotypes (gene matching)

cleft palate / MGI
abnormal rib morphology / MGI
absent kidney / MGI
enlarged liver sinusoidal spaces / MGI
abnormal thyroid gland morphology / MGI
abnormal thymus morphology / MGI
abnormal forebrain morphology / MGI
abnormal lens morphology / MGI
hemorrhage / MGI
aphakia / MGI
abnormal eye muscle morphology / MGI
absent ureter / MGI
abnormal Wolffian duct morphology / MGI
abnormal optic stalk morphology / MGI
abnormal optic cup morphology / MGI
fusion of vertebral arches / MGI
abnormal inferior vena cava morphology / MGI
abnormal common bile duct morphology / MGI
abnormal optic chiasm morphology / MGI
muscular ventricular septal defect / MGI
dual inferior vena cava / MGI
abnormal basilar artery morphology / MGI
absent segment of posterior cerebral artery / MGI
subcutaneous edema / MGI
abnormal ductus venosus valve morphology / MGI
abnormal infrahyoid muscle connection / MGI
blood in lymph vessels / MGI
abnormal vertebral artery topology / MGI
abnormal Wolffian duct connection / MGI

Information on how we integrate external resources can be found here

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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