C57BL/6N-Atm1Brd Arsgtm1a(KOMP)Wtsi/WtsiH

Status

Available to order

EMMA IDEM:14029
Citation informationRRID:IMSR_EM:14029 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Arsgtm1a(KOMP)Wtsi/WtsiH
Alternative nameEPD0332_2_G12
Strain typeTargeted Mutant Strains
Allele/Transgene symbolArsgtm1a(KOMP)Wtsi
Gene/Transgene symbolArsg
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from KOMP ES clone EPD0332_2_G12. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
References
  • Functional analysis of candidate genes from genome-wide association studies of hearing.;Ingham Neil J, Rook Victoria, Di Domenico Francesca, James Elysia, Lewis Morag A, Girotto Giorgia, Buniello Annalisa, Steel Karen P, ;2020;Hearing research;387;107879; 31927188

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • abnormal microglial cell morphology / MGI
  • abnormal hepatocyte morphology / MGI
  • abnormal Purkinje cell morphology / MGI
  • decreased Purkinje cell number / MGI
  • decreased exploration in new environment / MGI
  • abnormal spatial learning / MGI
  • abnormal learning/memory/conditioning / MGI
  • abnormal kidney morphology / MGI
  • abnormal macrophage morphology / MGI
  • abnormal neuron morphology / MGI
  • astrocytosis / MGI
  • impaired passive avoidance behavior / MGI
  • abnormal kidney epithelium morphology / MGI
  • lysosomal protein accumulation / MGI
  • abnormal perivascular macrophage morphology / MGI
  • microgliosis / MGI
  • abnormal liver sinusoid morphology / MGI
  • abnormal hippocampus neuron morphology / MGI
  • abnormal thalamus neuron morphology / MGI
  • abnormal glycosaminoglycan level / MGI

Literature references

  • Functional analysis of candidate genes from genome-wide association studies of hearing.;Ingham Neil J, Rook Victoria, Di Domenico Francesca, James Elysia, Lewis Morag A, Girotto Giorgia, Buniello Annalisa, Steel Karen P, ;2020;Hearing research;387;107879; 31927188

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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